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| http://dx.doi.org/10.1016/j.gendis.2024.101395 | DOI Listing |
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CARM1-induced lncRNA NEAT1 synchronously activates MYCN and GalNAcT-I to accelerate the progression of neuroblastoma.
Gene
February 2025
Department of Pediatric Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Purpose: Long non-coding RNAs (lncRNAs) play important roles in progression of neuroblastoma (NB). LncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) has been shown to affect the development of multiple tumors. However, the effect of NEAT1 on NB remain unclear.
View Article and Find Full Text PDFCARM1 accelerates the growth of liver cancer cells by enhancing ARAF.
Genes Dis
January 2025
Shanghai Putuo People's Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
CARM1 phosphorylation at S595 by p38γ MAPK drives ROS-mediated cellular senescence.
Redox Biol
October 2024
Muscle Physiome Research Center and Research Institute of Pharmaceutical Sciences, Sookmyung Women's University, Seoul, 04310, Republic of Korea; College of Pharmacy, Sookmyung Women's University, Seoul, 04310, Republic of Korea. Electronic address:
CARM1 is predominantly localized in the nucleus and plays a pivotal role in maintaining mitochondrial homeostasis by regulating gene expression. It suppresses mitochondrial biogenesis by downregulating PGC-1α and TFAM expression, while promoting mitochondrial fission through increased DNM1L expression. Under oxidative stress, CARM1 translocates to the cytoplasm, where it directly methylates DRP1 and accelerates mitochondrial fission, enhancing reactive oxygen species (ROS) production.
View Article and Find Full Text PDFCarm1-arginine methylation of the transcription factor C/EBPα regulates transdifferentiation velocity.
Elife
June 2023
Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Here, we describe how the speed of C/EBPα-induced B cell to macrophage transdifferentiation (BMT) can be regulated, using both mouse and human models. The identification of a mutant of C/EBPα (C/EBPα) that greatly accelerates BMT helped to illuminate the mechanism. Thus, incoming C/EBPα binds to PU.
View Article and Find Full Text PDFCircHULC accelerates the growth of human liver cancer stem cells by enhancing chromatin reprogramming and chromosomal instability via autophagy.
Cell Signal
September 2023
Shanghai Putuo People's Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China. Electronic address:
Background: Although CircHULC was overexpressed in several cancers, the role of CircHULC in malignancies has yet to be elucidated.
Methods: Gene infection, tumorigenesis test in vitro and in vivo and the signaling pathway analysis were performed.
Results: our results indicate that CircHULC promotes growth of human liver cancer stem cells and the malignant differentiation of hepatocyte-like cells.
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