AI Article Synopsis
- The study examined the link between low hand grip strength and the risk of osteoporosis (OP) and falling among patients, using Mendelian randomization for analysis.
- Results indicated that low hand grip strength is significantly associated with a higher risk of OP and falls, while it does not influence bone mineral density at various ages.
- The findings suggest that improving hand grip strength could be vital in preventing OP and falls, highlighting the need for targeted prevention strategies.
Article Abstract
Background: Patients with osteoporosis (OP) are often associated with decreased hand grip strength and increased risk of falling. It remains unclear whether there is a genetic causal between hand grip strength and OP, falling risk.
Methods: The Mendelian randomization study was used to investigate the genetic causal effect of low hand grip strength on total body bone mineral density (BMD) at different ages, OP, and falling risk. Genes for low hand grip strength, total body BMD at different ages, OP, and falling risk were obtained from published genome-wide association studies. Inverse variance weighted, MR-Egger, and weighted median were applied to perform the MR analysis. The Cochran's Q test, MR-Egger intercept test, MR-PRESSO global test, and leave-one-out analysis were used to detect the pleiotropy or heterogeneity.
Results: The results showed strong evidence that low hand grip strength was positively associated with OP (OR: 1.006, 95% CI: 1.003-1.010; P= 0.0001) and falling risk (OR: 1.069, 95% CI: 1.013-1.129; P= 0.0160), and could not directly affect the different ages of total body BMD (P> 0.05). There was no heterogeneity or horizontal pleiotropy in the sensitivity analysis (all P> 0.05).
Conclusion: The study found a positive causal relationship between low hand grip strength and higher risk of OP and falling, which should be taken into account in the development of future prevention and screening strategies for OP and falling.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11479888 | PMC |
| http://dx.doi.org/10.3389/fendo.2024.1433805 | DOI Listing |
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