Exploring the potential link between ΔFosB and -acetylcysteine in craving/relapse dynamics: can -acetylcysteine stand out as a possible treatment candidate? | LitMetric
Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Published: October 2024
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Article Abstract
From a neuroscientific point of view, one of the unique archetypes of substance use disorders is its road to relapse, in which the reward system plays a crucial role. Studies on the neurobiology of substance use disorders have highlighted the central role of a protein belonging to the Fos family of transcription factors, ΔFosB. Relying on the roles ΔFosB plays in the pathophysiology of substance use disorders, we endeavour to present some evidence demonstrating that -acetylcysteine, a low-cost and well-tolerated over-the-counter medicine, may influence the downstream pathway of ΔFosB, thereby serving as a treatment strategy to mitigate the risk of relapse in cases of substance use.
Background: The substance use crisis continues to progress. Medication for Opioid Use Disorder (MOUD) are prescribed to reduce opioid use and related harms; however, many individuals continue to use substances while on treatment. The objective of this study was to describe the temporal and demographic trends of the agreement between self-reported and urine tested substances.
Background Food addiction (FA), where an individual displays a loss of control over the consumption of calorie-dense foods (refined carbohydrates, fats), is proposed to be like substance-use disorders with the experience of cravings, reduced control over intake, increased impulsivity, and altered reward-sensitivity. FA may also be associated with obesity. This study aimed to determine the prevalence of FA in urban and rural areas, and the proportion of obesity in young adults with FA.
The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Provincial Engineering Research Center of Ecological Food Innovation, Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry, School of Public Health Guizhou Medical University Guiyang Guian New Area China.
is a type of plant that is used both for medicinal and food. (MS) are rich in volatile oil and have initially been employed to treat diseases of the nervous system. Insomnia, a prevalent neurological disorder, has led to this study's aim: to extract the essential oil from MS and analyze its potential to improve sleep.
Vitiligo, a prevalent cutaneous depigmentation disorder, often leads individuals to seek cosmetic remedies such as dihydroxyacetone (DHA)-infused camouflage makeup. Wood's lamp, a common diagnostic tool in dermatology, is typically employed to assess vitiligo lesions, revealing DHA-induced fluorescence in a distinct salmon color, contrasting with the bright blue-white fluorescence exhibited by vitiligo lesions. Erythrasma, a bacterial infection of the epidermis, is known for its unique bright coral-pink or coral-red fluorescence under Wood's lamp.
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China;3. University of Chinese Academy of Sciences, Beijing 100049, China.
Post-transcriptional ribonucleic acid (RNA) modifications play crucial roles in regulating gene expression, with both eukaryotic and prokaryotic RNA exhibiting more than 170 distinct and ubiquitous modifications. RNA turnover generates numerous free nucleosides, including unmodified nucleosides and a variety of modified ones. Unlike unmodified nucleosides, modified nucleosides are not further degraded or used in the salvage-synthesis pathway owing to a lack of specific enzymes, which leads to the cytosolic accumulation or cellular efflux of modified nucleosides.
