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A High-Sensitivity Fiber Optic Soil Moisture Sensor Based on D-Shaped Fiber and Tin Oxide Thin Film Coatings.
Sensors (Basel)
November 2024
Mechanical and Systems Research Laboratory, Industrial Technology Research Institute, Hsinchu 310401, Taiwan.
We present a high-sensitivity fiber optic soil moisture sensor based on side-polished multimode fibers and lossy mode resonance (LMR). The multimode fibers (MMFs), after side-polishing to form a D-shaped structure, are coated with a single-layer SnO thin film by electron beam evaporation with ion-assisted deposition technology. The LMR effect can be obtained when the refractive index of the thin film is positive and greater than its extinction coefficient and the real part of the external medium permittivity.
View Article and Find Full Text PDFCross-neutralization of distant coronaviruses correlates with Spike S2-specific antibodies from immunocompetent and immunocompromised vaccinated SARS-CoV-2-infected patients.
Res Sq
December 2024
Biology Department, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA.
As of May 2023, the public health emergency of COVID-19 was lifted across the globe. However, SARS-CoV-2 infections continue to be recorded worldwide. This situation has been attributed to the ability of the virus to evade host immune responses including neutralizing antibody-derived Immunity.
View Article and Find Full Text PDFGlobal Insights from Patients, Providers, and Staff on Challenges and Solutions in Managing Neovascular Age-Related Macular Degeneration.
Ophthalmol Ther
December 2024
International Federation on Ageing, Toronto, ON, Canada.
Introduction: Neovascular age-related macular degeneration is a global public-health concern, associated with a considerable burden to individuals, healthcare systems, and society. The objective of this study was to understand different perspectives on the challenges associated with the clinical management of neovascular age-related macular degeneration, which could elucidate measures to comprehensively improve clinical care and outcomes.
Methods: A survey was carried out of patients with neovascular age-related macular degeneration, their providers, and clinic staff in 77 clinics across 24 countries on six continents, from a diverse range of healthcare systems, settings, and reimbursement models.
Improving Clinical Management of Diabetic Macular Edema: Insights from a Global Survey of Patients, Healthcare Providers, and Clinic Staff.
Ophthalmol Ther
December 2024
International Federation on Ageing, Toronto, ON, Canada.
Introduction: In contrast with patients receiving therapy for retinal disease during clinical trials, those treated in routine clinical practice experience various challenges (including administrative, clinic, social, and patient-related factors) that can often result in high patient and clinic burden, and contribute to suboptimal visual outcomes. The objective of this study was to understand the challenges associated with clinical management of diabetic macular edema from the perspectives of patients, healthcare providers, and clinic staff, and identify opportunities to improve eye care for people with diabetes.
Methods: We conducted a survey of patients with diabetic macular edema, providers, and clinic staff in 78 clinics across 24 countries on six continents, representing a diverse range of individuals, healthcare systems, settings, and reimbursement models.
Enhanced radiotherapy susceptibility in NSCLC through palbociclib-mediated PP5 inhibition.
Biochim Biophys Acta Mol Cell Res
November 2024
Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan. Electronic address:
Article Synopsis
- * Our study found that the protein PP5 is more highly expressed in NSCLC tissues than in normal tissues, and high levels of PP5 are linked to worse survival rates, especially in patients receiving radiotherapy.
- * We demonstrated that the drug palbociclib targets PP5 and improves the effectiveness of radiotherapy by causing DNA damage and activating AMPK, leading to cell death; these findings suggest that targeting PP5 could be a promising strategy for overcoming radioresistance in NSCLC.
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