AI Article Synopsis
- * Researchers developed a pneumatic microneedle patch that uses live Enterobacter aerogenes as microengines, which generate gas to actively control drug delivery by pushing drugs deeper into the skin.
- * The system demonstrates over 200% increased drug delivery depth and effectively delivers calcitriol in a psoriasis animal model, showcasing significant potential for enhanced drug efficiency and on-demand control.
Article Abstract
As a transdermal drug delivery method, microneedles offer minimal invasiveness, painlessness, and precise in-situ treatment. However, current microneedles rely on passive diffusion, leading to uncontrollable drug penetration. To overcome this, we developed a pneumatic microneedle patch that uses live Enterobacter aerogenes as microengines to actively control drug delivery. These microbes generate gas, driving drugs into deeper tissues, with adjustable glucose concentration allowing precise control over the process. Our results showed that this microorganism-powered system increases drug delivery depth by over 200%, reaching up to 1000 μm below the skin. In a psoriasis animal model, the technology effectively delivered calcitriol into subcutaneous tissues, offering rapid symptom relief. This innovation addresses the limitations of conventional microneedles, enhancing drug efficiency, transdermal permeability, and introducing a creative paradigm for on-demand controlled drug delivery.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11484856 | PMC |
| http://dx.doi.org/10.1038/s41467-024-53280-8 | DOI Listing |
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