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The Transcription Factor SOX18 Inhibitor Small Molecule 4 Is a Potential Treatment of Cancer-Induced Lymphatic Metastasis and Lymphangiosarcoma.
Cancer Rep (Hoboken)
January 2025
Department of Plastic, Hand, and Reconstructive Microsurgery, BG Unfallklinik Frankfurt Am Main, Affiliated Hospital of Goethe-University, Frankfurt am Main, Germany.
Background: Malignant tumors release growth factors, promoting lymphangiogenesis in primary tumors and draining sentinel lymph nodes, ultimately facilitating lymph node metastasis. As a malignant lymphatic tumor entity, lymphangiosarcomas are characterized by low survival rates and limited treatment options. The transcription factor SOX18 plays a crucial role in both lymphatic endothelial cell differentiation and cancer-induced lymphangiogenesis.
View Article and Find Full Text PDFShort-term Postoperative Complications of Lymphatic Malformation Surgical Excision: A 20-Year Institutional Review.
J Pediatr Surg
January 2025
Division of Pediatric Surgery, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Objective: To evaluate outcomes and postoperative complications following surgical resection of lymphatic malformations (LMs) at a single multidisciplinary vascular anomalies center.
Methods: A single-center retrospective review of all patients ≤21 years old who underwent surgical resection of a lymphatic malformation at a quaternary referral center with a multidisciplinary vascular anomalies team from 2004 to 2024. Data pertaining to postoperative outcomes and treatments was abstracted.
A comprehensive review of computational diagnostic techniques for lymphedema.
Prog Biomed Eng (Bristol)
January 2025
Amrita Vishwa Vidyapeetham, Center for Wireless Networks & Applications (WNA), Amrita Vishwa Vidyapeetham Amritapuri, Kollam, India, Kollam, 690525, INDIA.
Lymphedema is localized swelling due to lymphatic system dysfunction, often affecting arms and legs due to fluid accumulation. It occurs in 20% to 94% of patients within 2 to 5 years after breast cancer treatment, with around 20% of women developing breast cancer-related lymphedema (BCRL). This condition involves the accumulation of protein-rich fluid in interstitial spaces, leading to symptoms like swelling, pain, and reduced mobility that significantly impact quality of life.
View Article and Find Full Text PDFEffective Management Strategies for Primary Lymphedema of the Lower Extremities: Integrating Conservative and Surgical Therapies in Early and Late Stages.
Microsurgery
January 2025
Division of Plastic Surgery, China Medical University Hospital, Taichung, Taiwan.
Introduction: Lymphedema, a debilitating characterized by localized fluid retention and tissue swelling, results from abnormalities in the lymphatic system. In the case of primary lymphedema, this condition is attributed to malformations in lymphatic vessels or nodes, and it is marked by a relentless progression leading to irreversible tissue fibrosis after repetitive inflammation. Many questions regarding its treatment, such as the choice of the type of intervention and the timing, still remain unanswered.
View Article and Find Full Text PDFScreening Lymphatic Ultrasound to Detect Lymphatic Dysfunction.
Lymphat Res Biol
January 2025
Lymphedema Clinic Tokyo, Tokyo, Japan.
We currently perform noncontrast lymphatic ultrasound, which has a higher resolution and is less invasive than contrast lymphatic ultrasound. This study aimed to clarify the usefulness of screening lymphatic ultrasound (SLUS) to evaluate lymphatic function. A retrospective study was conducted on 22 patients with leg lymphedema.
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