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Real-World Experience with CDK4/6 Inhibitors in the First-Line Palliative Setting for HR+/HER2- Advanced Breast Cancer.
Curr Oncol
January 2025
Schulich School of Medicine and Dentistry, Western University, London, ON N6A 3K7, Canada.
Introduction: CDK4/6 inhibitors in combination with aromatase inhibitors (AIs) are the standard first-line treatment for hormone receptor-positive (HR+), HER2-negative (HER2-) metastatic breast cancer. Landmark trials have demonstrated a comparable progression-free survival (PFS) across CDK4/6 inhibitors, but the overall survival (OS) outcomes have varied. This study aimed to evaluate the real-world PFS and OS for palbociclib and ribociclib when combined with AIs in patients with HR+/HER2- advanced breast cancer.
View Article and Find Full Text PDFAre standardized conditions needed for correct CGM data interpretation in subjects at early stages of glucose intolerance?
Diabetol Metab Syndr
January 2025
Department of Endocrinology, Medical University of Sofia, 2 Zdrave Str., 1431, Sofia, Bulgaria.
Aim: The present study comparatively evaluated glucose variability (GV) parameters derived from both continuous glucose monitoring (CGM) performed under standard conditions for a 24-h period and under usual everyday conditions for a 14-day period in a high-risk population without diabetes.
Methods And Results: Seventy five subjects: 14 with normal glucose tolerance (NGT; mean age 43.6 ± 10.
Lupus Nephritis Renal Response in a Real-World Setting in Argentina.
J Clin Rheumatol
January 2025
From the Rheumatology Section, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Objective: To identify the percentage of patients with incident lupus nephritis who achieved primary efficacy renal response (PERR) and complete renal response (CRR) after 2 years of treatment at a university hospital.
Methods: An observational study including patients with lupus with a first renal biopsy with nephritis class III, IV, or V, or combined, performed between years 2000 and 2018 and follow-up for over 2 years at a university hospital in Argentina. The proportion of patients with PERR and CRR at 1 and 2 years and the proportion of patients requiring rescue therapy were calculated.
Effects of tongue tamers and customized bonded spurs as an early treatment of anterior open bite: a randomized clinical study.
BMC Oral Health
January 2025
Department of Pediatric Dentistry, Oral Health, and Preventive Dentistry, Faculty of Dentistry, Tanta University, Tanta, 31527, Egypt.
Background: Anterior open bite is a challenging condition for pediatric dentists and orthodontists as it causes aesthetic, speech, feeding, and psychological problems; this emphasizes the need for early diagnosis and interception of this malocclusion.
Aim: This study aimed to evaluate the effects of prefabricated metal-bonded tongue tamers and customized bonded spurs in the early treatment of anterior open bite.
Materials And Methods: A sample of seventy-five children aged 7-9 years were assigned into three groups in which anterior open bite was treated using tongue tamers (group-I), customized composite bonded spurs(group-II), and conventional fixed palatal cribs (group-III).
Myocardial Abnormalities Across the AHA/ACC Stages of Heart Failure in Patients With Diabetes.
JACC Asia
December 2024
Departments of Magnetic Resonance Imaging, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Background: Cardiac magnetic resonance imaging (CMR) could serve as a robust tool for comprehensive evaluation of early changes across heart failure (HF) stages classified by the American Heart Association/American College of Cardiology guideline in diabetes mellitus (DM).
Objectives: The authors aimed to explore phenotypic imaging features characterizing DM participants at different HF stages by CMR.
Methods: DM participants with preserved ejection fraction who underwent CMR examination between January 2020 and December 2021 were evaluated.
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