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Paternal metformin use and risk of congenital malformations in offspring in Norway and Taiwan: population based, cross national cohort study.
BMJ
October 2024
PharmacoEpidemiology and Drug Safety Research Group, Department of Pharmacy, University of Oslo, Oslo, Norway.
Objective: To evaluate the association between paternal metformin use and risk of congenital malformations in offspring.
Design: Population based, cross national cohort study.
Setting: Norway and Taiwan.
Paternal metformin use and congenital malformations in offspring.
BMJ
October 2024
Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, VIC, Australia.
Paternal and Maternal Metformin Use and the Risk for Major Congenital Malformations.
Ann Intern Med
July 2024
Reproductive Medicine Research Group, School of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom.
Paternal Use of Metformin During the Sperm Development Period Preceding Conception and Risk for Major Congenital Malformations in Newborns.
Ann Intern Med
July 2024
Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts (S.H.).
Background: Metformin is the most used oral antidiabetic medication. Despite its established safety profile, it has known antiandrogenic and epigenetic modifying effects. This raised concerns about possible adverse developmental effects caused by genomic alterations related to paternal use of metformin during the spermatogenesis period preceding conception.
View Article and Find Full Text PDFUnraveling Potential Sex-Specific Effects of Cardiovascular Medications on Longevity Using Mendelian Randomization.
J Am Heart Assoc
December 2023
School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong Hong Kong China.
Background: Establishing the sex-specific efficacy of cardiovascular medications is pivotal to evidence-based clinical practice, potentially closing the gender gap in longevity. Trials large enough to establish sex differences are unavailable. This study evaluated sex-specific effects of commonly prescribed cardiovascular medications on lifespan.
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