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http://dx.doi.org/10.1016/j.amjmed.2024.10.010 | DOI Listing |
ACG Case Rep J
January 2025
Stony Brook Medicine, Department of Medicine, Division of Gastroenterology and Hepatology, Stony Brook University Hospital, Stony Brook, NY.
Although herpes simplex virus, Epstein-Barr virus, and hemophagocytic lymphohistiocytosis are known causes of severe acute liver injury with or without liver failure, these diseases occur almost exclusively in immunocompromised and elderly patients. We report a case of an immunocompetent young man with no medical history who presented with a subacute cough and persistent fevers in the setting of a penile chancre. He was found to have severely elevated liver chemistries and was subsequently diagnosed with hemophagocytic lymphohistiocytosis because of disseminated herpes simplex virus type 1 and Epstein-Barr virus coinfection.
View Article and Find Full Text PDFHum Vaccin Immunother
December 2025
Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, NSW, Australia.
Herpes zoster (HZ) is increasingly common in the aging and is experienced by approximately one in three people in their lifetime. It is also relatively common in immune-compromised people. Acute HZ causes severe pain, reduced quality of life and severe complications, including prolonged pain, or postherpetic neuralgia (PHN), and ocular zoster, which may rarely progress to blindness.
View Article and Find Full Text PDFCureus
December 2024
Internal Medicine, One Brooklyn Health, New York, USA.
We present a case report of a 72-year-old female with a history of stage III rectal adenocarcinoma undergoing chemotherapy who developed neutropenic sepsis and acute respiratory failure. The patient was admitted to the intensive care unit (ICU) due to worsening respiratory status and was subsequently diagnosed with disseminated herpes simplex virus (HSV) infection including acute respiratory distress syndrome (ARDS). This case highlights the challenges in diagnosing and managing HSV infection in critically ill patients and emphasizes the importance of early recognition and appropriate treatment in improving patient outcomes.
View Article and Find Full Text PDFCell Mol Biol (Noisy-le-grand)
November 2024
Department of Zoology, Bacha Khan University, Charsadda 24420, Khyber Pakhtunkhwa, Pakistan.
The present study aimed to examine the impact of Ricinus communis and valacyclovir (VACV) on the progression of skin lesions and pain responses in mice infected with herpes simplex virus type 1 (HSV-1). Mice were infected with HSV-1 and treated with R. communis (8, 16, or 48 mg/kg) or VACV (8, 25, or 90 mg/kg) twice daily on days 2-8 post-infection.
View Article and Find Full Text PDFRev Med Liege
December 2024
Service de Dermatologie et Vénéréologie, CHU Liège, Belgique.
Shingles, also termed herpes zoster (HZ), is due to the reactivation of the varicella zoster virus (VZV) in a dorsal root nerve ganglion with an intra-axonal passage of the virus to a predetermined dermatome. The risk of HZ increases with age, as well as the morbidity risks. The most feared complication is post-herpetic neuralgia, defined as persisting pain sensations three months after the resolution of the skin lesions.
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