Advancements in therapeutic peptides: Shaping the future of cancer treatment.

Biochim Biophys Acta Rev Cancer

China-US (Henan) Hormel Cancer Institute, Zhengzhou 450003, China; Research Center of Basic Medicine Sciences, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China. Electronic address:

Published: November 2024

In the evolving landscape of cancer treatment, therapeutic peptides are assuming to play an increasingly vital role. Although the number of peptide drugs available for clinical cancer treatment is currently limited, extensive preclinical research is underway, presenting a promising trajectory for the future. The collaborative efforts of natural anti-cancer peptides (ACPs) and synthetic ACPs, propelled by advancements in molecular biology and peptide chemistry, are steering remarkable progress in this domain. We explores the intricate mechanisms underlying the anti-cancer effects of these peptides. The exploration of innovative strategies, including cancer immunotherapy and advanced drug delivery systems, is likely to contribute to the increasing presenceuse of peptide drugs in clinical cancer care. Furthermore, we delve into the potential implications and challenges associated with this anticipated shift, emphasizing the need for continued research and development to unlock the full therapeutic potential of peptide drugs in cancer treatment.

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http://dx.doi.org/10.1016/j.bbcan.2024.189197DOI Listing

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