More than one shade of pink as a marker of early amelanotic/hypomelanotic melanoma.

J Dermatol

Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.

Published: July 2024

AI Article Synopsis

  • * The study analyzed 133 digital images of skin lesions diagnosed as either early amelanotic melanoma or non-melanocytic lesions, using assessments by three blinded dermatologists.
  • * Results indicated specific features in lesions (like multiple shades of pink and irregular dots) can significantly increase the likelihood of accurate diagnosis of early amelanotic melanoma compared to non-melanoma lesions.

Article Abstract

Amelanotic/hypomelanotic melanoma (AHM) may be difficult to diagnose because of a lack of pigmentation. To evaluate whether dermoscopy can be useful for the diagnosis of early AHM, 133 digital dermoscopic images of lesions histopathologically diagnosed as amelanotic/hypomelanotic superficial spreading melanoma with ≤1 mm thickness (AHSSMs) (n = 27), amelanotic/hypomelanotic non-melanocytic lesions (AHNMLs) (e.g., seborrhoeic keratosis and basal cell carcinoma) (n = 79), and amelanotic/hypomelanotic benign melanocytic lesions (AHBMLs) (e.g., compound and dermal nevi) (n = 27), were dermoscopically assessed by three blinded dermatologists. Using multivariate analysis, we found a significantly increased risk of diagnosing AHSSM versus AHNML and AHBML when the lesion was characterized by the presence of more than one shade of pink (odds ratio [OR] 37.11), irregular dots/globules (OR 23.73), asymmetric pigmentation (OR 8.85), and structureless pattern (OR 7.33). In conclusion, dermoscopy may improve early AHM detection, discriminating AHSSM from amelanotic/hypomelanotic non melanoma lesions.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11483925PMC
http://dx.doi.org/10.1111/1346-8138.17200DOI Listing

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