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PD-L1 expression and characterization of its carrier macrophages in placentas with acute and specifically post-SARS-CoV-2 infection.
Histochem Cell Biol
November 2024
Department of Biotechnology Engineering, Braude College of Engineering, Karmiel, Israel.
At the beginning of the coronavirus disease 2019 (COVID-19) pandemic, uncertainties about the virus and its dangers during pregnancy caused great uncertainty and fear, especially among pregnant women. New data suggest an increased risk of obstetric complications, including maternal complications, preterm labor, intrauterine growth restriction, hypertensive disorders, stillbirths, gestational diabetes and risk, of neonatal developmental disorders. In addition, preeclampsia (PE)-like syndromes were also induced by severe COVID-19 infection.
View Article and Find Full Text PDFThe association of maternal COVID-19-infection during pregnancy on the neonatal immune profile and associations with later diagnosis of neurodevelopmental disorders.
Brain Behav Immun
January 2025
Department of Internal Medicine, Division of Rheumatology, Allergy, and Clinical Immunology, University of California, Davis, CA, USA; Department of Medical Microbiology and Immunology, University of California, Davis, CA, USA; MIND Institute, University of California, Davis, CA, USA. Electronic address:
Despite the prevalence and significant concern of COVID-19 in maternal and offspring health, little is known about the impact of COVID-19 during pregnancy on newborn immunity and neurodevelopment. This study aimed to examine 1) the relationship between maternal COVID-19 during pregnancy and newborn immune profiles and investigate the 2) associations between specific newborn immune profiles and the risk of subsequent diagnosis of a neurodevelopmental disorder (NDD) among children with prenatal exposure to COVID-19. Newborn dried bloodspots (NBS) from 545 children born at Kaiser Permanente Northern California between January 2020 and September 2021 (460 [223 males, 237 females] to COVID-19-infected [COVID+] mothers; 85 [45 males, 40 females] to COVID-19-uninfected [COVID-] mothers) were used to profile newborn immune molecules via a 42-plex cytokine/chemokine assay.
View Article and Find Full Text PDFInvestigating the impact of severe maternal SARS-CoV-2 infection on infant DNA methylation and neurodevelopment.
Mol Psychiatry
October 2024
Department of Psychiatry, Monash University, Clayton, Vic, Australia.
Maternal infections during pregnancy can increase the risk to offspring of developing a neurodevelopmental disorder. Given the global prevalence and severity of infection with Severe Acute Respiratory Syndrome related Coronavirus 2 (SARS-CoV-2), the objective of this study was to determine if in utero exposure to severe maternal SARS-CoV-2 infection alters infant neurodevelopmental outcomes at 12 months and to identify potential biological markers of adverse infant outcomes. Mother-infant dyads exposed to severe SARS-CoV-2 infection (requiring hospitalization) during pregnancy and age and sociodemographic matched control dyads were recruited from Monash Medical Centre, Australia in 2021/22 and prospectively assessed over 12 months.
View Article and Find Full Text PDFSARS-CoV-2 and Offspring Neurodevelopment-We Don't Know Yet.
JAMA Netw Open
October 2024
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston.
In Utero Exposure to Maternal COVID-19 and Offspring Neurodevelopment Through Age 24 Months.
JAMA Netw Open
October 2024
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco.
Article Synopsis
- The study investigates the impact of maternal COVID-19 infection during pregnancy on the neurodevelopmental outcomes of children at 12, 18, and 24 months of age.
- It utilizes data from the ASPIRE trial, which involved a diverse cohort of over 2,000 pregnant individuals from all states and Puerto Rico, who were enrolled remotely during the pandemic.
- Results show that children exposed to maternal COVID-19 had a higher prevalence of abnormal developmental scores compared to unexposed children, particularly at 12 months, indicating a potential link between the infection and developmental delays.
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