AI Article Synopsis
- - The study examines the effects of parasympathetic stimulation via the pterygopalatine ganglion (PPG) on choroidal structure, specifically looking at how electroacupuncture impacts choroidal thickness and vascularity in healthy adults.
- - In a crossover design, 22 participants underwent both PPG stimulation and sham stimulation, with measurements taken before and after each intervention, revealing significant increases in choroidal thickness and vascularity following PPG stimulation.
- - Results showed that while choroidal thickness peaked 15 minutes after stimulation and remained elevated for 60 minutes, choroidal vascularity peaked immediately and then gradually returned to baseline, highlighting the potential of PPG activation for influencing choroidal health
Article Abstract
Purpose: Choroidal dysfunction is implicated in various ocular pathologies. The parasympathetic pterygopalatine ganglion (PPG) innervates orbital vessels supplying the choroid. While PPG stimulation has been shown to dilate cerebral blood flow, its effects on the choroid, particularly in human subjects, require further elucidation. This study aimed to investigate the short-term influence of PPG stimulation via electroacupuncture on choroidal structure.
Methods: In this crossover study, 22 healthy adults received PPG electrical stimulation and sham stimulation for one session each on two separate days in a randomized order. Measurements including choroidal thickness (ChT), choroidal vascularity index (ChVI), central subfield thickness, axial length, anterior chamber depth, and lens thickness were recorded before and at intervals (0, 15, 30, 45, and 60 minutes) postintervention.
Results: The ChT on the side receiving PPG stimulation demonstrated a sustained increase, peaking at 15 minutes poststimulation (17.2 µm, P < 0.001) and persisting for up to 60 minutes. Conversely, the ChVI exhibited a more immediate response, with a peak increase immediately poststimulation (3.8%, P = 0.003), followed by a gradual return to baseline. ChT and ChVI in the contralateral eye showed a nonsignificant trend to decrease. Additionally, a notable reduction in ipsilateral axial length was observed at specific time points poststimulation.
Conclusions: PPG activation via electroacupuncture elicited a short-term increase in ChT and ChVI in the ipsilateral eye compared to sham stimulation, with ChT increases trailing those of ChVI but displaying greater persistence.
Translational Relevance: Electrical stimulation of the PPG can produce a short-term increase in ipsilateral ChT and ChVI.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11486082 | PMC |
| http://dx.doi.org/10.1167/tvst.13.10.26 | DOI Listing |
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Article Synopsis
- - The study examines the effects of parasympathetic stimulation via the pterygopalatine ganglion (PPG) on choroidal structure, specifically looking at how electroacupuncture impacts choroidal thickness and vascularity in healthy adults.
- - In a crossover design, 22 participants underwent both PPG stimulation and sham stimulation, with measurements taken before and after each intervention, revealing significant increases in choroidal thickness and vascularity following PPG stimulation.
- - Results showed that while choroidal thickness peaked 15 minutes after stimulation and remained elevated for 60 minutes, choroidal vascularity peaked immediately and then gradually returned to baseline, highlighting the potential of PPG activation for influencing choroidal health
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