AI Article Synopsis
- - This study investigates genetic variations in the GNLY and PTX3 genes and their link to acne in Egyptian individuals, highlighting the inflammatory nature of acne as a skin disorder.
- - The research included 180 acne patients and 180 healthy controls, using real-time PCR to analyze specific genetic polymorphisms (SNPs) related to these genes.
- - Results showed that the PTX3 rs2305619 variant is significantly associated with acne susceptibility, indicating that individuals with certain genotypes (AG + GG) are more likely to develop acne, while the GNLY rs7908 polymorphism does not show a similar association.
Article Abstract
This study aims to examine the genetic polymorphisms of the granulysin (GNLY) and pentraxin 3 (PTX3) genes and their association with acne in Egypt. Acne vulgaris is classified as a disorder of the pilosebaceous unit. Clinical, histological, and immunological findings indicate that inflammation is involved in every stage of acne development. GNLY and PTX3 are both involved in the body's immune system and may play a role in the pathophysiology of acne. This case-control study included 180 participants who have acne and 180 healthy controls. Real-time PCR was used to genotype GNLY rs7908 and PTX3 rs2305619 polymorphisms. Genotype occurrence and allelic spreading for both single nucleotide polymorphisms (SNP) are in Hardy-Weinberg equilibrium. Regarding rs7908, no statistical difference was observed in the genotype and allele distributions between acne patients and controls. On the other hand, rs2305619 showed a statistical difference in the genotype and allele distributions between acne patients and controls, with a marked prevalence of the GG group and G allele in acne patients. Our study revealed a significant link between the PTX3 rs2305619 and acne susceptibility in Egypt, with the AG + GG genotype strongly predicting acne. In contrast, the GNYL rs7908 polymorphism was not associated with acne. These results highlight a genetic component to acne and suggest that PTX3 rs2305619 could be a key marker for understanding acne susceptibility.
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| http://dx.doi.org/10.1007/s00403-024-03444-9 | DOI Listing |
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