AI Article Synopsis

  • The study aimed to compare the surgical performance of a new large-diameter composite polycarbonate polyurethane graft to a traditional polyester graft in patients undergoing thoracic aortic prosthesis replacement.
  • A review of 14 patients from 2016 to 2021 showed that the polycarbonate polyurethane graft group had significantly shorter operation times and less postoperative drainage and hospital stays compared to the polyester graft group.
  • The findings suggest that the new graft has promising properties, but further testing in a larger, multi-center trial is necessary for confirmation.

Article Abstract

Objective: The objective of this study was to compare the perioperative performance of the novel large-diameter composite polycarbonate polyurethane graft and the polyester graft.

Methods: In this study, we retrospectively analyzed 14 patients with thoracic aortic prosthesis replacement from 2016 to 2021. The preoperative, intraoperative, and postoperative data of the 2 groups were assessed in detail.

Results: We defined the patients with polyester grafts as the control group and the patients with polycarbonate polyurethane grafts as the experimental group. The total operation time of the experimental group was significantly shorter than that of the control group, which were 159.29±38.13 minutes and 252.57±64.40 minutes, respectively (p<0.001). The length of time from aortic opening to the end of operation in the experimental group was significantly shorter than that in the control group, which were 70.43±8.08 minutes and 124.71±37.59 minutes, respectively (p<0.001). The mean total drainage of pleural fluid was lower in the experimental group than in the control group (383.43±139.68 mL vs. 828.00±457.27 mL; p<0.05). The mean postoperative in-hospital time was shorter in the experimental group than in the control group (6.71±0.75 days vs. 9.43±2.82 days; p<0.05).

Conclusions: This study provides preliminary evidence that the novel artificial blood vessel has good mechanical properties, histocompatibility, hemocompatibility, and anti-seepage function in the human body. A multicenter randomized controlled trial is needed for further validation.

Clinical Impact: The novel hybrid polycarbonate polyurethane (PCU)/polyester three-layered large-diameter artificial blood vessel simulates the internal, middle, and external layers of the human blood vessels. The inner and outer layer are made of PCU, and the middle reinforcing layer is woven by polyester. Because of the three-layered structure, this artificial blood vessel has excellent anti-seepage and anti-infection functions. the inner and outer layers of the blood vessel made of PCU let this artificial blood vessel has excellent blood compatibility, outstanding biocompatibility, high endothelialization rate, and 100% patency. By comparing the perioperative outcomes with the polyester artificial blood vessel, we find it has good mechanical properties, histocompatibility, hemocompatibility and anti-seepage function in the human body.

Download full-text PDF

Source
http://dx.doi.org/10.1177/15266028241283363DOI Listing

Publication Analysis

Top Keywords

polycarbonate polyurethane
8
artificial blood
8
blood vessel
8
control group
8
experimental group
8
perioperative outcomes
4
outcomes polycarbonate
4
polyurethane artificial
4
vessel versus
4
versus polyester
4

Similar Publications

This study aimed to enhance the initial adhesion performance of reactive polyurethane hot-melt adhesives by using a bio-based polycarbonate polyol instead of traditional polyester or polyether polyols and by incorporating thermoplastic polyurethane (TPU) in varied proportions. Adhesives synthesized from bio-based polycarbonate polyols and polypropylene glycol with MDI as the isocyanate were characterized chemically, thermally, and mechanically (FTIR, DSC, plate-plate rheology, DMA, and T-peel strength test). Adding 10-15 wt.

View Article and Find Full Text PDF

The recent COVID-19 pandemic and the prospect of future global pandemics highlight the long-standing need to passively eliminate viruses and bacteria on surfaces. Conventional antimicrobial surfaces and coatings are typically constrained by a trade-off between antimicrobial efficacy and physical durability. A biphasic polyurethane coating has been developed that breaks this trade-off by incorporating a durability-imparting polycarbonate (PC) discrete phase with a continuous poly(ethylene glycol) (PEG) transport phase that absorbs, stores, and releases antimicrobial active compounds for extended microbial inactivation.

View Article and Find Full Text PDF

Chemical upcycling of poly(bisphenol A carbonate) via sequential diamino-/methanolysis: A phosgeneless one-pot route to dimethyl dicarbamate esters.

J Hazard Mater

November 2024

Università degli Studi "Aldo Moro" di Bari, Dipartimento di Chimica, Campus Universitario, Via E. Orabona, 4, 70126 Bari, Italy; Centro Interdipartimentale di Ricerca su Metodologie e Tecnologie Ambientali (METEA), via Celso Ulpiani 27, 70126 Bari, Italy. Electronic address:

Waste poly(bisphenol A carbonate) (PC) is a potential source of harmful bisphenol A (BPA). In this study a new approach aiming to chemically valorize hazardous PC wastes is described. A one-pot process has been developed that allows to recover BPA from PC used as "phosgene equivalent" for the synthesis of dimethyl dicarbamates MeOCNH-R-NHCOMe.

View Article and Find Full Text PDF

Background: Chronic venous insufficiency (CVI) is a common disease with a high prevalence. Incompetent venous valves are considered as one of the main causes. Besides compression therapy, various surgical therapies are practiced, whereby the reconstruction of valves is of central importance.

View Article and Find Full Text PDF

Dynamic non-covalent interactions between polycarbonate soft segments have been proposed for explaining the intrinsic self-healing of polyurethanes synthesized with polycarbonate polyols (PUs) at 20 °C. However, these self-healing PUs showed insufficient mechanical properties, and their adhesion properties have not been explored yet. Different PUs with self-healing at 20 °C, acceptable mechanical properties, and high shear strengths (similar to the highest ones reported in the literature) were synthesized by using blends of polycarbonate polyols of molecular weights 1000 and 2000 Da (CD1000 + CD2000).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!