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Evaluation of Optic Disc Drusen Using Modern Imaging Paraclinical Methods.
Cesk Slov Oftalmol
December 2024
Purpose: To analyze patients with optic disc drusen (ODD), with emphasis on modern diagnostics.
Materials And Methods: Research of the literature was conducted, together with a retrospective statistical analysis of patients with ODD. The group included individuals with ODD diagnosed using at least one of the following (ultrasound - USG, optical coherence tomography - OCT, fundus autofluorescence - FAF).
Guselkumab in patients with moderately to severely active ulcerative colitis (QUASAR): phase 3 double-blind, randomised, placebo-controlled induction and maintenance studies.
Lancet
December 2024
Department of Medicine I, Agaplesion Markus Hospital, Goethe University, Frankfurt, Germany.
Background: Interleukin-23 inhibition is effective in treating ulcerative colitis. Guselkumab is a dual-acting, human IgG1, interleukin-23p19 subunit inhibitor that potently neutralises interleukin-23 and can bind to CD64. We aimed to evaluate the efficacy and safety of guselkumab as induction and maintenance therapy in patients with ulcerative colitis.
View Article and Find Full Text PDFCase report: Satralizumab as an adjunctive therapy for AQP-4 antibody and MOG antibody dual-negative optic neuritis in a third-trimester pregnancy case.
Front Med (Lausanne)
December 2024
Department of Ophthalmology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China.
The treatment of demyelinating optic neuritis (DON) in pregnant patients is challenging, especially when there is poor or no response to intravenous methylprednisolone pulse (IVMP) therapy or adjunctive treatments such as intravenous immunoglobulin (IVIG) therapy. We herein report a case of a 28-year-old pregnant woman who experienced sequential severe vision loss in both eyes. She presented to a local hospital with the main complaint of sudden, painless vision loss in the left eye and was diagnosed with DON in the left eye.
View Article and Find Full Text PDFEvaluation of optical coherence tomography and optical coherence tomography angiography findings of fibromyalgia.
Int Ophthalmol
December 2024
Eye Clinic, University of Health Sciences Umraniye Training and Research Hospital, 34766, Umraniye, Istanbul, Turkey.
Background: To execute comprehensive study about optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) findings in fibromyalgia (FM) to elaborate macula, optic disk changes.
Methods: A total of 84 participants comprising 44 FM patients and 40 healthy controls were included. Macular full thickness, retinal nerve fiber layer (RNFL), ganglion cell layer (GCL)+, GCL++, superficial vessel density (SVD), deep vessel density (DVD), foveal avascular zone (FAZ), circumpapillary vessel density (cpVD), RNFL measurements were evaluated using OCT/OCTA.
Axial elongation in nonpathologic high myopia: Ocular structural changes and glaucoma diagnostic challenges.
Asia Pac J Ophthalmol (Phila)
December 2024
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China. Electronic address:
Axial elongation continues in highly myopic adult eyes, even in the absence of pathologic changes such as posterior staphyloma or chorioretinal atrophy. This ongoing axial elongation leads to structural changes in the macular and peripapillary regions, including chorioretinal thinning, reduced vascular perfusion and optic disc tilting and rotation, among others. These alterations can affect the acquisition and interpretation of optical coherence tomography, optical coherence tomography angiography and fundus photographs, potentially introducing artifacts and diminishing the accuracy of glaucoma diagnosis in highly myopic eyes.
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