Background: Mohs micrographic surgery (MMS) offers high cure rates for nonmelanoma skin cancer (NMSC) but relies on precise margin assessment, traditionally initiated by the naked eye. Dermoscopy has emerged as a potential tool to improve margin delineation.
Objective: To compare the efficacy of dermoscopic versus naked eye evaluation in marking initial MMS margins for NMSC.
Methods: A multicenter, prospective study on patients with NMSC undergoing MMS was conducted. Patients were randomized into dermoscopy and naked eye groups. Statistical analysis was performed using statistical package for social sciences.
Results: A total of 127 patients were enrolled, with 63 in the naked eye group and 64 in the dermoscopy group. No significant differences in age, sex distribution, or histological subtype were found. The average number of MMS stages and accuracy of initial margins were comparable between groups.
Discussion: Despite its potential, the authors' study found no significant reduction in total MMS stages using dermoscopy. Novel imaging modalities or standardized dermoscopic criteria should be explored to enhance margin assessment accuracy and improve outcomes in NMSC treatment.
Conclusion: Dermoscopic evaluation of presurgical margins does not effectively assess lateral/deep margins nor contribute to a reduction in total MMS stages. Improving the authors' understanding of presurgical margin assessment techniques can lead to better treatment outcomes for NMSC.
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http://dx.doi.org/10.1097/DSS.0000000000004455 | DOI Listing |
Front Plant Sci
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Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China.
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Department of Chemistry, University of South Florida, Tampa, Florida 33620, USA.
Sodium dodecyl sulfate (SDS) is widely used in numerous household products and pharmaceuticals due to its excellent water solubility, emulsification, foaming, and dispersing properties. However, the extensive use of SDS has made it a significant environmental pollutant, posing a great threat to aquatic ecosystems. Therefore, developing a rapid, efficient, and sensitive probe for detecting SDS in aqueous environments is crucial.
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Department of Food Science and Technology, College of Agriculture, Isfahan University of Technology, Isfahan 84156-83111, Iran. Electronic address:
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The Key Laboratory for Biomedical Photonics of MOE at Wuhan National Laboratory for Optoelectronics-Hubei Bioinformatics & Molecular Imaging Key Laboratory, Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.
Cysteamine (CA) serves as a cystine-depleting agent employed in the management of cystinosis and a range of other medical conditions. Monitoring blood CA levels at the point of care is imperative due to the risk of toxicity associated with elevated CA dosages. An additional significant challenge is presented by the intricate composition of human plasma and the presence of various interfering biological thiols, which possess similar structures or properties.
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School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, PR China.
Wearable sensors have broad application potential in motion assessment, health monitoring, and medical diagnosis. However, relying on a specialized instrument for power supply and signal reading makes sensors unsuitable for on-site detection. To solve this problem, a reusable self-powered electrochromic sensor patch based on enzymatic biofuel cells were constructed to realize the on-site visualized monitoring.
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