Introduction: Liposomes were extensively used for cosmetics and pharmaceuticals due to their versatility, biocompatibility, and biodegradability, as well as the ability to encapsulate water-soluble and fat-soluble substances. However, some challenges remain unsolved, including poor stability, complex preparation process, limited encapsulation efficiencies (EE%) and drug loading capacity (DLC%).
Method: We herein prepared universal liquid proliposomes by rotary evaporation method and optimized formulations with different pH, glycerol content, ethanol content and preparation process.
Result: The EE% of water-soluble substances was above 85%, and the maximum DLC% was 37.5%. In 7 different conditions, the optimal formulation of the proliposomes remained stable over 60 days. The excellent stability of proliposomes and nicotinamide liposomes and their essence, when applied to cosmetic formulations, was confirmed by the Turbiscan stability analyzer.
Conclusion: The proposed universal liquid proliposomes can form liposomes encapsulating a variety of water-soluble substances rapidly, making them an accessible and versatile tool for improving the stability and applicability of water-soluble raw materials.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2174/0113892010328982241004064135 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Activity waves in condensed excitable phases of Quincke rollers.
Soft Matter
January 2025
Center for Soft Condensed Matter Physics and Interdisciplinary Research & School of Physical Science and Technology, Soochow University, Suzhou 215006, P. R. China.
Traveling waves are universal in excitable systems; yet, the microscopic dynamics of wave propagation is inaccessible in conventional excitable systems. Here, we show that active colloids of Quincke rollers driven by a periodic electric field can form condensed excitable phases. Distinct from existing excitable media, condensed excitable colloids can be tuned reversibly between active liquids and active crystals in which two distinct waves can be excited, respectively.
View Article and Find Full Text PDFTemplated self-organization of polymer-tethered gold nanoparticles into freestanding superlattices at the liquid-air interface.
Phys Chem Chem Phys
January 2025
College of Materials and Textile Engineering, Jiaxing University, Jiaxing 314001, China.
Programmable organization of uniform organic/inorganic functional building blocks into large-scale ordered superlattices has attracted considerable attention since the bottom-up self-organization strategy opens up a robust and universal route for designing novel and multifunctional materials with advanced applications in memory storage devices, catalysis, photonic crystals, and biotherapy. Despite making great efforts in the construction of superlattice materials, there still remains a challenge in the preparation of organic/inorganic hybrid superlattices with tunable dimensions and exotic configurations. Here, we report the spontaneous self-organization of polystyrene-tethered gold nanoparticles (AuNPs@PS) into freestanding organic/inorganic hybrid superlattices templated at the diethylene glycol-air interface.
View Article and Find Full Text PDFPredicting coefficient of volume compressibility of fine-grained soils using appropriate soil type and soil state parameters.
Sci Rep
January 2025
Department of Civil Engineering, B.M.S. College of Engineering, Bangalore, Karnataka, 560019, India.
Predicting the coefficient of volume compressibility (m) would help a field engineer to make a quick estimate of the soil compressibility. The multiple correlations suggested by various researchers as available in the literature indicate the importance of predicting the m of soil. The existing correlations as available in literature either use soil state (in the form of SPT N-value or unconfined compressive strength or natural water content) or soil type (in the form of plasticity properties).
View Article and Find Full Text PDFPrediction of Proteolysis-Targeting Chimeras Retention Time Using XGBoost Model Incorporated with Chromatographic Conditions.
J Chem Inf Model
January 2025
School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, People's Republic of China.
Proteolysis-targeting chimeras (PROTACs) are heterobifunctional molecules that target undruggable proteins, enhance selectivity and prevent target accumulation through catalytic activity. The unique structure of PROTACs presents challenges in structural identification and drug design. Liquid chromatography (LC), combined with mass spectrometry (MS), enhances compound annotation by providing essential retention time (RT) data, especially when MS alone is insufficient.
View Article and Find Full Text PDFApplication of aqueous two-phase extraction for separation and purification of various adeno-associated viruses.
Biotechnol Lett
January 2025
Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Zhejiang Key Laboratory of Smart Biomaterials, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310058, China.
Objective: Adeno-associated viruses (AAVs) are widely used as gene therapy vectors due to their safety, stability, and long-term expression characteristics. The objective of this work is to develop an aqueous two-phase system (ATPS) as a universal platform for the separation and purification of AAVs.
Results: This study utilized polyethylene glycol (PEG)/salt ATPSs to separate and purify various AAV serotypes, including AAV5, AAV8, and AAV9, which focusing on serotype-specific performance and partial empty capsid removal.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!