AI Article Synopsis
- The study aimed to evaluate how effective and safe aripiprazole, bromocriptine, and cabergoline are for treating hyperprolactinemia through a network meta-analysis of randomized controlled trials (RCTs).
- A total of 44 RCTs with 3,886 patients were analyzed, revealing that cabergoline combined with conventional therapy was most effective in lowering prolactin levels, especially in non-drug-induced cases.
- The findings suggested that different dopamine receptor agonists have specific advantages: cabergoline for non-drug-induced cases, aripiprazole for cases induced by antipsychotics or antidepressants, and bromocriptine for improving estrogen levels.
Article Abstract
Objective: To assess the efficacy and safety of aripiprazole, bromocriptine, and cabergoline in the treatment of hyperprolactinemia (HPRL) using network meta-analysis.
Method: We searched PubMed, Cochrane Library, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang, VIP, and China Biology Medicine disc (CBMdisc) for randomized controlled trials (RCTs). The quality of the included studies was assessed using the Cochrane risk-of-bias tool, and data were analyzed using RevMan 5.4, R 4.3.3, and Stata 17.
Results: 44 RCTs involving a total of 3886 patients were finally included. The results showed that at 12 week of treatment, cabergoline plus conventional therapy had optimal efficacy in reducing prolactin (PRL) levels. Cabergoline plus conventional therapy was most effective in reducing PRL levels in patients with non-drug-induced HPRL. Aripiprazole plus conventional therapy had optimal efficacy in reducing PRL levels in patients with antipsychotics-induced or antidepressant-induced HPRL. Bromocriptine was the most efficacious intervention in improving estrogen (E) levels.
Conclusion: Three dopamine receptor agonists (DAs) have different advantages in improving serum PRL and E levels in HPRL patients.
Prospero Id: CRD42024510695.
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| http://dx.doi.org/10.1080/14740338.2024.2416918 | DOI Listing |
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