AI Article Synopsis
- - Panama has experienced endemic Dengue virus (DENV) transmission since 1993, with all four serotypes present but no local DENV-4 cases reported since 2000, despite its ongoing circulation in nearby countries.
- - In the last four months of 2023, DENV-4 was detected in Panama, coinciding with a rise in dengue cases during the typically dry season, which is unusual since outbreaks are usually seen during the rainy season.
- - Analysis of complete DENV-4 genomes revealed that the recent cases were due to genotype IIb, the same as what was seen 23 years ago, showing the need for ongoing surveillance of dengue serotypes and genotypes to catch emerging variants early.
Article Abstract
Panama is a country with endemic Dengue virus (DENV) transmission since its reintroduction in 1993. The four serotypes have circulated in the country and the region of the Americas, however, DENV-4 confirmed autochthonous cases have not been identified since 2000, despite its circulation in neighboring countries. Here, we report DENV-4 detection in Panama in the last four-month period of 2023 with co-circulation of the other serotypes, this was associated with a peak of dengue cases during the dry season even though most dengue outbreaks are described in the rainy season. Complete genomes of DENV-4 allowed us to determine that cases were caused by DENV-4 genotype IIb, the same genotype as 23 years ago, with high similarity to DENV-4 sequences circulating in Nicaragua and El Salvador during 2023. This report shows the importance of maintaining serotype and genotype surveillance for early detection of new variants circulating in the country.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11473613 | PMC |
| http://dx.doi.org/10.3389/fcimb.2024.1467465 | DOI Listing |
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