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| http://dx.doi.org/10.3389/fphar.2024.1429435 | DOI Listing |
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Efficacy of esketamine for chronic post-thoracotomy pain: protocol for a systematic review and meta-analysis.
BMJ Open
December 2024
Department of Anesthesiology, Henan Provincial Chest Hospital & Chest Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Introduction: Chronic post-thoracotomy pain (CPTP) is a persistent and disabling condition affecting a significant proportion of patients after thoracotomy and posing a challenge for clinicians, despite advances in surgical and pain management strategies. Esketamine, the S-enantiomer of ketamine, has emerged as a promising therapeutic agent for various pain conditions, with evidence for its effectiveness in alleviating acute and chronic pain. This systematic review and meta-analysis will be conducted to assess the efficacy of esketamine in treating CPTP, and evaluate its effectiveness in reducing pain intensity, improving functional outcomes, and reducing opioid consumption, as well as its adverse effects.
View Article and Find Full Text PDFChallenges for esketamine nasal spray in China: use and management.
Front Pharmacol
October 2024
The Affiliated Mental Health Center of Jiangnan University, Wuxi Central Rehabilitation Hospital, Wuxi, Jiangsu, China.
Efficacy of nonopioid analgesics and adjuvants in multimodal analgesia for reducing postoperative opioid consumption and complications in obesity: a systematic review and network meta-analysis.
Br J Anaesth
December 2024
Department of Medicine - DIMED, Section of Anaesthesiology and Intensive Care, University of Padova, Padova, Italy; Institute of Anaesthesia and Intensive Care, Padua University Hospital, Padova, Italy.
Article Synopsis
- Managing postoperative pain for patients with obesity is complicated, and this study explores the effectiveness of various nonopioid intravenous analgesics and adjuvants in reducing opioid use and recovery complications after surgery.
- A systematic review of 37 randomized controlled trials found that medications like dexmedetomidine, ketamine, lidocaine, and gabapentin significantly decreased opioid consumption and postoperative issues such as nausea and vomiting in these patients.
- The findings suggest that these nonopioid analgesics are vital in improving postoperative care, ultimately leading to better outcomes for obese patients undergoing surgery.
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