New naphtho[2,1-]furan-2,5-dione and isocoumarin derivatives from bambusicolous fungus .

Nat Prod Res

Centre of Excellence for Innovation in Chemistry (PERCH-CIC), Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.

Published: October 2024

Two new compounds, 6-hydroxy-1-(4-hydroxyphenyl)naphtho[2,1-]furan-2,5-dion () and 3-methyl-6--L-rhamnopyranosyl-2-chromen-2-one (), along with three known compounds (-) were isolated from the rare bambusicolous fungus . The structures were elucidated through the analysis of IR, NMR and HRESIMS spectrographic data. Compound exhibited cytotoxicity against HeLa, HT29, MCF-7 and PC-3 cells, but was not toxic against normal Vero cells. The most abundant metabolite, oosporein (), exhibited significant cytotoxic effects against all tested cancer cells.

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Source
http://dx.doi.org/10.1080/14786419.2024.2416500DOI Listing

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