AI Article Synopsis
- Jayne et al. reveal the molecular details of a specific chromosomal translocation (t(1;6)(p35.3;p25.2)) found in chronic lymphocytic leukaemia patients.
- This translocation involves the IRF4 gene on chromosome 6 and the RCC1 gene on chromosome 1, indicating a fusion between RCC1 and IRF4.
- The study suggests that this chromosomal abnormality could have significant prognostic implications for patients with this type of leukaemia.
Article Abstract
Jayne et al. provide a molecular characterization of the t(1;6)(p35.3;p25.2) chromosomal translocation in patients with chronic lymphocytic leukaemia. They indicate that this translocation involves the gene encoding interferon regulatory factor 4 (IRF4) on chromosome 6p25.2 with the regulator of chromosome condensation 1 (RCC1) gene on chromosome 1p35.3. This translocations may have important prognostic value. Commentary on: Jayne et al. The chromosomal translocation t(1;6)(p35.3;p25.2), recurrent in chronic lymphocytic leukaemia leads to RCC1::IRF4 fusion. Br J Haematol 2024; 205:2321-2326.
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