Emulating the Delivery of Sawtooth Proton Arc Therapy Plans on a Cyclotron-Based Proton Beam Therapy System.

Cancers (Basel)

Department of Physics and Astronomy and the Cockcroft Institute, School of Natural Sciences, Faculty of Science and Engineering, The University of Manchester, Manchester M13 9PL, UK.

Published: September 2024

AI Article Synopsis

  • The study compares 'sawtooth' proton arc therapy (PAT) and static intensity modulated proton therapy (IMPT) in terms of their deliverability at a clinical facility.
  • It evaluates various PAT plans on different types of targets, including abdominal and brain cases, using both step-and-shoot and continuous delivery methods.
  • Results indicate that continuous PAT takes significantly longer in delivery time compared to static IMPT, and while the emulator can model PAT, it shows no evident advantage in beam-on time versus static IMPT, needing further validation.

Article Abstract

: To evaluate and compare the deliverability of 'sawtooth' proton arc therapy (PAT) plans relative to static intensity modulated proton therapy (IMPT) at a cyclotron-based clinical facility. : The delivery of single and dual arc Sawtooth PAT plans for an abdominal CT phantom and multiple clinical cases of brain, head and neck (H&N) and base of skull (BoS) targets was emulated under the step-and-shoot and continuous PAT delivery regimes and compared to that of a corresponding static IMPT plan. : Continuous PAT delivery increased the time associated with beam delivery and gantry movement in single/dual PAT plans by 4.86/7.34 min (brain), 7.51/12.40 min (BoS) and 6.59/10.57 min (H&N) on average relative to static IMPT. Step-and-shoot PAT increased this delivery time further by 4.79 min on average as the delivery was limited by gantry motion. : The emulator can approximately model clinical sawtooth PAT delivery but requires experimental validation. No clear benefit was observed regarding beam-on time for sawtooth PAT relative to static IMPT.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11475827PMC
http://dx.doi.org/10.3390/cancers16193315DOI Listing

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