AI Article Synopsis
- Syntaxin 3 is part of a protein family crucial for the fusion of vesicles with membranes, impacting various cellular processes.
- Mutations in the syntaxin 3A splice form are linked to a serious gut disorder, while additional mutations involving syntaxin 3B can lead to early-onset retinal diseases.
- The review focuses on new research highlighting the functions of syntaxin 3B in membrane fusion and neurotransmitter release specifically in the vertebrate retina.
Article Abstract
Syntaxin 3 is a member of a large protein family of syntaxin proteins that mediate fusion between vesicles and their target membranes. Mutations in the ubiquitously expressed syntaxin 3A splice form give rise to a serious gastrointestinal disorder in humans called microvillus inclusion disorder, while mutations that additionally involve syntaxin 3B, a splice form that is expressed primarily in retinal photoreceptors and bipolar cells, additionally give rise to an early onset severe retinal dystrophy. In this review, we discuss recent studies elucidating the roles of syntaxin 3B and the regulation of syntaxin 3B functionality in membrane fusion and neurotransmitter release in the vertebrate retina.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11476516 | PMC |
| http://dx.doi.org/10.3390/ijms251910665 | DOI Listing |
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