AI Article Synopsis
- Phenazine natural products are colored nitrogen-based compounds produced by various microorganisms from marine and terrestrial sources, known for their diverse chemical structures and pharmacological activities.
- These compounds exhibit a range of biological effects, including antimicrobial, anticancer, antiparasitic, anti-inflammatory, and insecticidal properties, making them valuable for medicine and agriculture.
- The review compiles over 150 phenazine variants and summarizes their antimicrobial and anticancer capabilities, serving as a resource for future research in this field.
Article Abstract
Phenazine natural products are a class of colored nitrogen-containing heterocycles produced by various microorganisms mainly originating from marine and terrestrial sources. The tricyclic ring molecules show various chemical structures and the decorating groups dedicate extensive pharmacological activities, including antimicrobial, anticancer, antiparasitic, anti-inflammatory, and insecticidal. These secondary metabolites provide natural materials for screening and developing medicinal compounds in the field of medicine and agriculture due to biological activities. The review presents a systematic summary of the literature on natural phenazines in the past decade, including over 150 compounds, such as hydroxylated, -methylated, -methylated, -oxide, terpenoid, halogenated, glycosylated phenazines, saphenic acid derivatives, and other phenazine derivatives, along with their characterized antimicrobial and anticancer activities. This review may provide guidance for the investigation of phenazines in the future.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11477647 | PMC |
| http://dx.doi.org/10.3390/molecules29194771 | DOI Listing |
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