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GluN2D-containing NMDA receptors in parvalbumin neurons in the nucleus accumbens regulate nocifensive responses in neuropathic pain.
Neurobiol Dis
December 2024
Department of Psychiatry and Behavioral Sciences, Texas A&M University School of Medicine, College Station, TX 77845, USA. Electronic address:
Neuropathic pain presents a significant challenge, with its underlying mechanisms still not fully understood. Here, we investigated the role of GluN2C- and GluN2D-containing NMDA receptors in the development of neuropathic pain induced by cisplatin, a widely used chemotherapeutic agent. Through genetic and pharmacological strategies, we found that GluN2D-containing NMDA receptors play a targeted role in regulating cisplatin-induced neuropathic pain (CINP), while sparing inflammatory or acute pain responses.
View Article and Find Full Text PDFThe gut-brain axis: Unveiling the impact of xenobiotics on neurological health and disorders.
Prog Neuropsychopharmacol Biol Psychiatry
December 2024
Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra 441002, India. Electronic address:
The Gut-Brain Axis (GBA) is a crucial link between the gut microbiota and the central nervous system. Xenobiotics, originating from diverse sources, play a significant role in shaping this interaction. This review examines how these compounds influence neurotransmitter dynamics within the GBA.
View Article and Find Full Text PDFMental Health Literacy Among Female Community Health Workers: A Multi-setting Cross-sectional Study.
Indian J Psychol Med
December 2024
Dept. of Mental Health and Community Nursing, Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada, Yogyakarta, Indonesia.
Background: Mental health literacy among lay community health workers (CHWs) is crucial to ensuring that mental health services are accessible to all. This research explores the mental health literacy of community health workers in Indonesia.
Methods: A cross-sectional study was carried out among 454 female community health workers from various villages.
Beyond clinical observations: a scoping review of AI-detectable observable cues in borderline personality disorder.
Front Psychiatry
December 2024
Department of Psychology, Faculty of Arts, University of Maribor, Maribor, Slovenia.
Borderline Personality Disorder (BPD), impacting approximately 2% of adults worldwide, presents a formidable challenge in psychiatric diagnostics. Often underdiagnosed or misdiagnosed, BPD is associated with high morbidity and mortality. This scoping review embarks on a comprehensive exploration of observable cues in BPD, encompassing language patterns, speech nuances, facial expressions, nonverbal communication, and physiological measurements.
View Article and Find Full Text PDFSense of coherence, subjective burden, and anxiety and depression symptoms in caregivers of people with dementia: Causal dynamics unveiled by a longitudinal cohort study in Europe.
J Affect Disord
December 2024
Dementia Services Development Centre (DSDC) Wales, School of Health Sciences, Bangor University, United Kingdom. Electronic address:
Background: Sense of coherence (SOC) is a disposition to perceive things as comprehensible, manageable and meaningful. Lower SOC is associated with subjective burden and psychological morbidity in family caregivers, including in dementia. However, the evidence-base mainly comprises small-scale or cross-sectional studies.
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