AI Article Synopsis

  • Researchers developed a CuSe@LYC composite, using lycorine and CuSe nanoparticles, which can generate reactive oxygen species (ROS) when exposed to near-infrared-II (NIR-II) light.
  • Treatment with the composite and NIR-II significantly reduced scar-related markers and induced cell death in hypertrophic scar fibroblasts, showing promise for safe clinical applications in managing scars.

Article Abstract

The hypertrophic scar (HS) is a prevalent cutaneous fibrotic disorder that impacts both the aesthetic and functional aspects of the skin, there is an urgent need for a highly safe and effective approach to address the challenge of HS with thick and deep types. Inspired by the superior deep tissue penetrative ability of near-infrared-II (NIR-II) light and potential mitochondria ROS inducing effect of Chinese medicine lycorine (LYC), we fabricated a CuSe@LYC (CL) composite by encapsulating LYC on polyvinyl pyrrolidone (PVP) modified CuSe nanoparticles. After NIR-II irradiation, CL could induce the generation of reactive oxygen species (ROS) and mitochondrial damage in hypertrophic scar fibroblasts (HSFs). The subsequent release of cytochrome C (cyt-c) from mitochondria into the cytoplasm and upregulation of beclin1 leads to the activation of endogenous apoptosis and autophagy-mediated cell death. The CL + NIR-II treatment exhibited a pronounced anti-scarring effect in both in vitro and in vivo rabbit ear scar models, leading to a significant reduction in the fibrotic markers including Collagen I/III and α-smooth muscle actin (α-SMA). This study comprehensively investigated the crucial role of HSFs' autophagy in scar management and proposed a safe and effective therapy based on NIR-II laser for clinical application.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11481805PMC
http://dx.doi.org/10.1186/s12951-024-02876-9DOI Listing

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