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Crosstalk Between Macrophages and Breast Cancer Cells: Networking Within Tumors. | LitMetric

AI Article Synopsis

  • - Tumor-associated macrophages (TAMs) are key immune cells in the breast tumor microenvironment, categorized into M1 (anti-tumor) and M2 (pro-tumor) types, which influence cancer growth and progression. - TAMs promote tumor progression through various mechanisms, including supporting cancer cell growth, aiding in blood vessel formation (angiogenesis), and enabling cancer cells to escape the immune system. - The chapter highlights how TAMs interact with cancer cells and other cells within the tumor microenvironment through signaling pathways and communication methods, while also discussing potential therapeutic strategies to target TAMs for cancer treatment.

Article Abstract

Tumor associated macrophages (TAMs) are one of the most prominent immune cells in the breast tumor microenvironment (TME). TAMs are categorised into classically activated anti-tumorigenic M1 and alternatively activated pro-tumorigenic M2 macrophages. TAMs are known to promote cancer pathogenesis by facilitating cancer cell and cancer stem cell growth, angiogenesis, immune evasion, invasion, and migration. Consequently, TAMs drive cancer progression towards metastasis. This chapter describes the role of TME in driving monocyte recruitment and polarization toward the M2 phenotype. We also illustrate the modalities of intercellular networking such as paracrine signaling, exosomes, and tunneling nanotubes (TNTs) that TAMs and cancer cells employ within TME to communicate with each other and with other cells of TME to facilitate the dynamic process of cancer progression. Finally, we discuss the clinical implications of TAMs in breast cancer and potential therapeutic strategies targeting TAM recruitment, polarization, and TAM-mediated immune evasion for effective cancer therapy.

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Source
http://dx.doi.org/10.1007/978-3-031-65944-7_8DOI Listing

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