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Glucose-6-phosphate dehydrogenase regulates mitophagy by maintaining PINK1 stability.
Life Metab
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Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore.
Glucose-6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme in the pentose phosphate pathway (PPP) in glycolysis. Glucose metabolism is closely implicated in the regulation of mitophagy, a selective form of autophagy for the degradation of damaged mitochondria. The PPP and its key enzymes such as G6PD possess important metabolic functions, including biosynthesis and maintenance of intracellular redox balance, while their implication in mitophagy is largely unknown.
View Article and Find Full Text PDFNatural phytochemicals reverting M2 to M1 macrophages: A novel alternative Leishmaniasis therapy.
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Immunology lab, Biotechnology & Bioengineering, Indian Institute of Advanced Research, Gandhinagar, Gujarat, 382426, India. Electronic address:
Introduction: Leishmaniasis is a tropical parasitic disease caused by the protozoan Leishmania which remains a significant global health concern with diverse clinical manifestations. Transmitted through the bite of an infected sandfly, its progression depends on the interplay between the host immune response and the parasite. The disease outcome is linked to macrophage polarisation into M1 and M2 phenotypes.
View Article and Find Full Text PDFThe Modulatory Effect of Selol (Se IV) on Pro-Inflammatory Pathways in RAW 264.7 Macrophages.
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Chair and Department of Biochemistry, Medical University of Warsaw, Banacha 1, 02-097 Warszawa, Poland.
Selol is a semi-synthetic mixture of selenized triglycerides. The results of biological studies revealed that Selol exhibits several anticancer effects. However, studies on its potential anti-inflammatory activity are scarce, and underlying signaling pathways are unknown.
View Article and Find Full Text PDFOxidative Stress and the Central Nervous System.
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Istituto di Analisi dei Sistemi ed Informatica "Antonio Ruberti", National Research Council, 00185 Rome, Italy.
Reactive oxygen and nitrogen species (ROS; RNS) are natural bioproducts of cellular metabolism, particularly produced within the mitochondria during energy production [...
View Article and Find Full Text PDFMitochondrial Management of ROS in Physiological and Pathological Conditions.
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Department of Sciences and Technology, University of Naples Parthenope, Via Acton 38, 80133 Naples, Italy.
Mitochondria are found, with rare exceptions [...
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