Septic shock (SS), the most severe complication of sepsis, has always been a major challenge and research focus in the field of critical care treatment. SS is categorized as a distributive shock, where fluid resuscitation and the use of vasoactive drugs are the two standard measures for the clinical management of SS. However, it remains unclear how to accurately monitor macro-circulation, micro-circulation, and cellular metabolism indicators during the process of resuscitation, optimization, stabilization, and evacuation based on the dynamic pathophysiological processes of SS. This monitoring is essential to guide the comprehensive, individualized, and dynamic application of these two measures. Based on recent international management guidelines and literature review, the authors will propose relevant recommendations regarding the use of fluid therapy and vasoactive drugs.
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http://dx.doi.org/10.3760/cma.j.cn112147-20240703-00380 | DOI Listing |
Medicine (Baltimore)
December 2024
Department of Critical Care Medicine, Fuyang Infectious Disease Clinical College of Anhui Medical University, Fuyang, Anhui Province, China.
Rationale: The mortality rate associated with pulmonary hemorrhage induced by leptospirosis is notably high. Available treatment modalities are limited, and their efficacy has not been fully demonstrated. Here, we present the case report of a patient with leptospirosis-induced pulmonary hemorrhagic syndrome.
View Article and Find Full Text PDFZhonghua Wei Zhong Bing Ji Jiu Yi Xue
November 2024
Department of Gastroenterology, Shanghai Pudong New Area People's Hospital, Shanghai 201299, China. Corresponding author: Zhao Guangkuo, Email: Chang Yunli, Email:
Objective: To investigate the prognostic value of albumin (ALB), aspartate aminotransferase/alanine aminotransferase ratio (AST/ALT) in patients with acute liver failure (ALF) in hyperacute phase of sepsis which provided the basis for clinical evaluation and prognostic judgment and corresponding treatment options.
Methods: A multicenter retrospective cohort study was conducted. Patients with ALF in hyperacute phase of sepsis admitted to Zhoupu Hospital Affiliated to Shanghai Health College, Shanghai Pudong New Area People's Hospital, and Shanghai Oriental Hospital from January 2019 to February 2024 were enrolled.
Molecules
December 2024
Department of Biotechnology, Chemistry, and Pharmacy, University of Siena, 53100 Siena, TS, Italy.
The huge amount of citrus peel produced worldwide represents an economic burden for society. However, this agricultural by-product is a rich source of natural molecules, potentially endowed with interesting pharmacological activities. In this regard, we decided to investigate if the polymethoxyflavones contained in citrus peel waste could be exploited as novel vasorelaxant agents.
View Article and Find Full Text PDFFront Oncol
November 2024
Department of Anesthesiology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Background: Early mortality rate in patients with high-risk pulmonary embolism(PE) is extremely high. Prompt and effective reduction of the thrombus load, and restoration of pulmonary circulation may successfully treat such patients. For patients with hemodynamic instability and high-risk acute PE, the guidelines recommend catheter directed therapy (CDT).
View Article and Find Full Text PDFBMJ Open
December 2024
Federal University of Sergipe, Sao Cristovao, Brazil
Background: Patients with moderate and severe traumatic brain injury (TBI) admitted to the intensive care unit (ICU) may develop pressure injury (PI) due to haemodynamic instability caused by the disease, lack of mobility in bed, as well as intense and prolonged compression in prominent bone areas.
Objective: The objective of this review is to assess the incidence and identify risk factor for the development of PI in patients with moderate and severe TBI admitted to the ICU.
Method: Searches were conducted in the PubMed, CINAHL, Scopus, Embase, Web of Science, Google Scholar, Trove and Open Grey databases, including all records found up to May 2023.
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