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Developmental Haploinsufficiency in Medial Ganglionic Eminence-Derived Interneurons Impairs Auditory Cortex Activity, Social Behavior, and Extinction of Fear Memory. | LitMetric

AI Article Synopsis

  • Mutations in the SYNGAP1 protein can lead to intellectual disabilities, epilepsy, autism, and sensory issues, with existing research highlighting its role in glutamatergic synapse development, but its function in GABAergic neurons is still not well understood.
  • The study investigates how reducing SYNGAP1 expression specifically in different types of GABAergic neurons (PV and SST interneurons) affects brain function and behavior in mice.
  • Findings indicate that decreased SYNGAP1 in Nkx2.1-expressing neurons causes abnormal brain activity and social behavior problems, suggesting that disruptions in PV interneurons may be linked to cognitive changes seen in SYNGAP1-related disorders.

Article Abstract

Mutations in SYNGAP1, a protein enriched at glutamatergic synapses, cause intellectual disability associated with epilepsy, autism spectrum disorder, and sensory dysfunctions. Several studies showed that Syngap1 regulates the time course of forebrain glutamatergic synapse maturation; however, the developmental role of Syngap1 in inhibitory GABAergic neurons is less clear. GABAergic neurons can be classified into different subtypes based on their morphology, connectivity, and physiological properties. Whether expression specifically in parvalbumin (PV)-expressing and somatostatin (SST)-expressing interneurons, which are derived from the medial ganglionic eminence (MGE), plays a role in the emergence of distinct brain functions remains largely unknown. We used genetic strategies to generate haploinsufficiency in (1) prenatal interneurons derived from the medial ganglionic eminence, (2) in postnatal PV cells, and (3) in prenatal SST interneurons. We further performed in vivo recordings and behavioral assays to test whether and how these different genetic manipulations alter brain function and behavior in mice of either sex. Mice with prenatal-onset haploinsufficiency restricted to Nkx2.1-expressing neurons show abnormal cortical oscillations and increased entrainment induced by 40 Hz auditory stimulation but lack stimulus-specific adaptation. This latter phenotype was reproduced in mice with haploinsufficiency restricted to PV, but not SST, interneurons. Prenatal-onset haploinsufficiency in Nkx2.1-expressing neurons led to impaired social behavior and inability to extinguish fear memories; however, neither postnatal PV- nor prenatal SST-specific mutant mice show these phenotypes. We speculate that haploinsufficiency in prenatal/perinatal PV interneurons may contribute to cortical activity and cognitive alterations associated with mutations.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622180PMC
http://dx.doi.org/10.1523/JNEUROSCI.0946-24.2024DOI Listing

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