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Laboratory of Pharmacology, Department of Natural Active Principles and Toxicology, São Paulo State University (UNESP), School of Pharmaceutical Sciences Rodovia Araraquara KM 01 (Campus Universitário), Araraquara, SP 14800-903, Brazil. Electronic address:

This study aimed to evaluate the influence of rat strain in expression of autonomic and cardiovascular changes during acute exposure to restraint stress, as well as in habituation of these physiological responses upon repeated exposure to restraint. For this, blood pressure, heart rate (HR) and sympathetically-mediated cutaneous vasoconstriction were assessed in Wistar (control strain), Long-Evans, Holtzman and spontaneously hypertensive (SHR) rats during acute or 10 60-min session of restraint stress. We observed that HR returned faster to baseline values during recovery of the acute session of restraint in Long-Evans and SHR rats in relation to Wistar, thus indicating shorter tachycardia in these strains.

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