Wound healing is delayed due to the infection and biofilm formation of antibiotic-resistant species of gram-negative bacteria especially Pseudomonas aeruginosa and Escherichia coli. Antibacterial photodynamic therapy provides an efficient therapeutic strategy for overcoming drug resistance by producing reactive oxygen species (ROS) and reactive nitrogen species (RNS). Here, we have designed a low-cost light emitting diode (LED) based reusable and non-invasive titanium dioxide nanoparticles patch which is sandwiched between the thin polymer layers. The light-induced pore formation in the polymeric film due to the free radical, in turn, passes through the system and kills the bacteria rather than nanoparticles entering the system resulting in the reusability nature of the patch. The patch's in vitro antibacterial and antibiofilm activity and their mechanism (synergic ROS-induced RNS) were studied. In addition, the reusable antibacterial properties, biocompatibility and wound-healing properties of the patch were also successfully elucidated.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.colsurfb.2024.114301 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Non-invasive, continuous oral delivery of solid levodopa-carbidopa for management of Parkinson's disease.
Sci Rep
November 2024
synAgile Corporation, Jackson, WY, 83001, USA.
When short plasma half-life drugs act only briefly, they require frequent or continuous administration. We report the engineering of a non-invasive oral drug delivery system for long-term, continuous administration of these drugs. Their non-invasive, long-term, continuous administration at daily doses exceeding 100 mg has, for many years, been considered an insurmountable challenge.
View Article and Find Full Text PDFReusable and non-invasive TiO-based photodynamic transdermal patch (RPT) for treating MDR-negative bacteria strain and promote wound healing through a synergistic approach of ROS-induced RNS.
Colloids Surf B Biointerfaces
January 2025
Department of Chemistry and Biochemistry, Jain (Deemed to be) University, Bengaluru, India. Electronic address:
Wound healing is delayed due to the infection and biofilm formation of antibiotic-resistant species of gram-negative bacteria especially Pseudomonas aeruginosa and Escherichia coli. Antibacterial photodynamic therapy provides an efficient therapeutic strategy for overcoming drug resistance by producing reactive oxygen species (ROS) and reactive nitrogen species (RNS). Here, we have designed a low-cost light emitting diode (LED) based reusable and non-invasive titanium dioxide nanoparticles patch which is sandwiched between the thin polymer layers.
View Article and Find Full Text PDFEngineering Thermoresponsive Poly(-isopropylacrylamide)-Based Films with Enhanced Stability and Reusability for Efficient Bone Marrow Mesenchymal Stem Cell Culture and Harvesting.
Molecules
September 2024
School of Civil Engineering, Liaoning Petrochemical University, Fushun 113001, China.
Poly(-isopropylacrylamide) (PNIPAM) offers a promising platform for non-invasive and gentle cell detachment. However, conventional PNIPAM-based substrates often suffer from limitations including limited stability and reduced reusability, which hinder their widespread adoption in biomedical applications. In this study, PNIPAM copolymer films were formed on the surfaces of glass slides or silicon wafers using a two-step film-forming method involving coating and grafting.
View Article and Find Full Text PDFPilot Assessment of Piezoelectric Transducers as a Cost-Effective Alternative to EndoPAT.
J Vasc Res
October 2024
School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada.
Article Synopsis
- - Current microvascular assessments are often impractical due to the need for experienced personnel and expensive equipment, prompting a need for alternative methods like piezoelectric transducers for measuring microvascular function.
- - In a study with 25 adults, researchers compared the effectiveness of piezoelectric transducers and EndoPAT in measuring microvascular function using reactive hyperemia tests, analyzing blood pressure wave signals from fingers.
- - The results showed a significant correlation between the Microvascular Function Index (MFI) from piezoelectric transducers and the Reactive Hyperemia Index (RHI) from EndoPAT, suggesting that MFI is a reliable, user-friendly alternative for assessing vascular health.
Effective manual cleaning as the first step of reprocessing glass probes of a medical device for non-invasive physical plasma therapy.
GMS Hyg Infect Control
June 2024
Physical Plasma Medicine Laboratories, Department of Gynecology and Gynecological Oncology, University Hospital Bonn, Bonn, Germany.
Background: For reusable devices and device components, effective reprocessing is essential to prevent nosocomial infections.
Aim: The objective of the study was to evaluate manual cleaning as the first step of reprocessing reusable glass probes of a device for generation of non-invasive physical plasma, in accordance with regulations.
Methods: Two glass probes of the device were contaminated with human blood.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!