Elucidating the immunomodulatory effects of phytoestrogens and their groundbreaking applications in transplantation medicine.

Int Immunopharmacol

Department of Immunology, Guilin Medical University, Guilin 541199, China; Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin 541199, China. Electronic address:

Published: December 2024

AI Article Synopsis

  • Phytoestrogens are plant-based compounds that mimic estrogen in the body, influencing immune cell behavior.
  • Diets high in polyphenols and flavonoids are linked to reduced inflammation, autoimmune issues, and lower cancer rates.
  • The study examines how phytoestrogens can help with immune regulation and improve outcomes in organ transplant patients, who typically face long-term complications from immunosuppressive drugs.

Article Abstract

Phytoestrogens are natural compounds found in plants and plant-based foods. When ingested, they can affect the human body in the same way as estrogen produced by the body. Phytoestrogens affect the regulation, differentiation, and production of immune cells. People who consume polyphenol and flavonoid-rich foods have lower incidences of inflammation, autoimmune diseases, and cancer. In organ transplantation, immune rejection is a lifelong problem for patients. In clinical practice, acute rejection is treated with hormonal shock or immunosuppressive drugs. However, effective reversal measures for chronic rejection, specifically for prevention, are still lacking. Recipients are also prone to post-transplant complications such as new tumors, diabetes, hyperlipidemia, hyperuricemia, and cardiovascular and cerebrovascular diseases, owing to the long-term use of immunosuppressive drugs. Phytoestrogens play a promising role in immune regulation and exert curative effects on cardiovascular diseases and cancer. In this study, we reviewed the use of phytoestrogens in the fields of immune regulation and organ transplantation.

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Source
http://dx.doi.org/10.1016/j.intimp.2024.113220DOI Listing

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