The effect of consuming a sucrose-containing sports drink on acute kidney injury risk during a 4 h simulated occupational heat stress.

Occupational heat stress increases acute kidney injury risk. Drinking a soft drink sweetened with high fructose corn syrup further elevates this acute kidney injury risk. However, the impact of sucrose, another fructose-containing sweetener, on acute kidney injury risk remains unexplored. We tested the hypothesis that drinking a sucrose-containing sports drink increases acute kidney injury risk when compared to drinking a sugar-free sports drink during 4 h of simulated occupational heat stress. Ten healthy adults consumed a sucrose-containing or sugar-free sport drink ad libitum during 4 h exposures to wet bulb globe temperatures of ∼28 °C. Thirty min of work and 30 min of rest were completed each hour. Work involved treadmill walking at a fixed rate of metabolic heat production (sucrose-containing: 6.0 ± 1.2 W/kg, sugar-free: 5.5 ± 0.9 W/kg,  = 0.267). The product of urinary insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase-2, normalized to urine specific gravity ([IGFBP7·TIMP-2]), provided an acute kidney injury risk index. Mean core (intestinal:  = 13, rectal:  = 7) temperature (sucrose-containing: 37.5 ± 0.1 °C, sugar-free: 37.5 ± 0.3 °C;  = 0.914), peak core temperature (sucrose-containing: 37.8 ± 0.2 °C, sugar-free: 37.9 ± 0.3 °C;  = 0.398), and percent changes in body mass (sucrose-containing: -0.5 ± 0.4%, sugar-free: -0.3 ± 0.6%;  = 0.386) did not differ between groups. [IGFBP7∙TIMP-2] increased in both groups (time effect:  = 0.025) with no drink ( = 0.675) or interaction ( = 0.715) effects. Peak change [IGFBP7∙TIMP-2] did not differ between sucrose-containing (median 0.0116 [-0.0012, 0.1760] (ng/mL)/1000) and sugar-free (median 0.0021 [0.0003, 0.2077] (ng/mL)/1000;  = 0.796). Sucrose-containing sports drink consumption during simulated occupational heat stress does not modify acute kidney injury risk when compared to sugar free-sport drink consumption.