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Clinical and ultrasound characteristics in patients with sars-cov-2 pneumonia, associated with hospitalization prognosis. e-covid project.
BMC Pulm Med
December 2024
Centre d'Atenció Primària Onze de Setembre. Gerència Territorial de Lleida, Institut Català de La Salut, Passeig 11 de Setembre,10 , 25005, Lleida, Spain.
Background: During the COVID-19 pandemia, the imaging test of choice to diagnose COVID-19 pneumonia as chest computed tomography (CT). However, access was limited in the hospital setting and patients treated in Primary Care (PC) could only access the chest x-ray as an imaging test. Several scientific articles that demonstrated the sensitivity of lung ultrasound, being superior to chest x-ray [Cleverley J et al.
View Article and Find Full Text PDFFish oil and vitamin D in pregnancy for the prevention of early childhood asthma: study protocol for two double-blinded, randomised controlled trials.
BMJ Open
December 2024
Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), Gentofte, Denmark.
Introduction: Previous randomised controlled trials (RCTs) have indicated a protective role of pregnancy supplementation with fish oil and high-dose vitamin D, respectively, on offspring asthma, infections and several other disorders in early childhood. However, current evidence is not considered sufficient for recommending these supplements in pregnancy. In two RCTs, we aim to investigate whether these protective effects can be confirmed in larger trials with the goal of changing clinical practice and improving child health.
View Article and Find Full Text PDFThe role of TBC1D15 in sepsis-induced acute lung injury: Regulation of mitochondrial homeostasis and mitophagy.
Int J Biol Macromol
December 2024
Department of Anesthesiology, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, Guangxi Zhuang Autonomous Region, China; Key Laboratory for Basic Science and Prevention of Perioperative Organ Disfunction, Guangxi Medical University Cancer Hospital, Nanning 530021, Guangxi Zhuang Autonomous Region, China. Electronic address:
Mitochondrial quality control is crucial in sepsis-induced acute lung injury (SI-ALI). Our study investigates how the intracellular protein TBC1D15 regulates mitochondrial quality to improve SI-ALI. We found TBC1D15 levels significantly decreased in the whole blood of sepsis patients, monocytes, lung tissue from SI-ALI mice, and the MLE-12 cellular model (mouse lung epithelial cells).
View Article and Find Full Text PDFGanoderic Acid a Potential Protective Impact on Bleomycin (BLM) -Induced lung Fibrosis in albino mice: Targeting Caveolin 1/TGF-β/ Smad and P38MAPK signaling pathway.
Arch Biochem Biophys
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Medical Biochemistry & Molecular Biology Department.
Background: Bleomycin (BLM), an anticancer medication, can exacerbate pulmonary fibrosis by inducing oxidative stress and inflammation. Anti-inflammatory, anti-fibrotic, and antioxidant properties are exhibited by ganoderic acid A (GAA).
Aim: So, we aim to assess GAA's protective impact on lung fibrosis induced via BLM.
Syringin alleviates ROS-induced acute lung injury by activating SIRT1/STAT6 signaling pathway to inhibit ferroptosis.
Tissue Cell
December 2024
Department of Neurosurgery, Huabei Petroleum Administration Bureau General Hospital, Renqiu, Hebei Province 062550, China. Electronic address:
Introduction: Acute lung injury (ALI) is the critical respiratory condition. Syringin with anti-inflammatory and anti-oxidant properties can exhibit the lung protective effects. SIRT1 and STAT6 can exert protective roles against lung injury by inhibiting ferroptosis.
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