AI Article Synopsis
- - The study investigated the impact of sedated versus unsedated colonoscopy on polyp/adenoma detection rates (PDR/ADR) among 11,504 patients from mid-2021 to late 2022.
- - Results showed that sedated colonoscopy was linked to significantly lower overall PDR/ADR, particularly in the right side of the colon and for both single and multiple polyps, suggesting it may hinder detection effectiveness.
- - The authors conclude that while sedated colonoscopy is widely used, it may not be advantageous for polyp detection and should only be recommended selectively, highlighting the need for further research to improve screening methods.
Article Abstract
Background: Sedated colonoscopy has been increasingly selected. However, the effect of sedated colonoscopy on polyp/adenoma detection rate (PDR/ADR) remains controversial among studies.
Methods: In this retrospective study, the medical records of 11 504 consecutive patients who underwent colonoscopy at our department from July 1, 2021 to December 31, 2022 were collected. Patients were divided into sedated and unsedated groups according to the use of intravenous sedation during colonoscopy. Overall PDR/ADR, right-side, transverse, and left-side colon PDR/ADR, and single and multiple PDR/ADR were calculated. By adjusting for age, gender, body mass index, inpatient, screening/surveillance, cecal intubation time, colonoscopy withdrawal time ≥6 min, and an endoscopist's experience ≥5 years, multivariate logistic regression analyses were performed to evaluate the association of sedated colonoscopy with overall PDR/ADR, right-side, transverse, and left-side colon PDR/ADR, and single and multiple PDR/ADR, where the absence of PDR/ADR was used as reference. Odds ratios (ORs) with their 95% confidence intervals (CIs) were calculated.
Results: Overall, 2275 patients were included, of whom 293 and 1982 underwent sedated and unsedated colonoscopy, respectively. Multivariate logistic regression analyses showed that sedated colonoscopy was independently associated with lower overall PDR/ADR (OR = 0.640, 95% CI = 0.460-0.889, = 0.008), right-side colon PDR/ADR (OR = 0.591, 95% CI = 0.417-0.837, = 0.003), single PDR/ADR (OR = 0.659, 95% CI = 0.436-0.996, = 0.048), and multiple PDR/ADR (OR = 0.586, 95% CI = 0.402-0.855, = 0.005), but not transverse or left-side colon PDR/ADR.
Conclusion: Sedated colonoscopy may not be beneficial in terms of overall PDR/ADR, right-side colon PDR/ADR, and number of polyps/adenomas. Thus, it should be selectively recommended. Additionally, it should be necessary to explore how to improve the quality of sedated colonoscopy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11481089 | PMC |
| http://dx.doi.org/10.1177/10732748241272482 | DOI Listing |
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Article Synopsis
- - The study aimed to identify and categorize discomfort symptoms following sedative-administered colonoscopy, with the goal of developing criteria to recognize postoperative fatigue syndrome (POFS).
- - Researchers conducted follow-up interviews with 542 patients who had undergone the procedure to collect data on 19 different discomfort symptoms, including fatigue, lethargy, and dizziness.
- - The key findings suggest that the main symptoms defining POFS are fatigue, lethargy, dizziness, and headache, which should be included in diagnostic criteria for this syndrome.
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