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Bacterial profile of wound site infections and evaluation of risk factors for sepsis among road traffic accident patients from Apex Trauma Centre, Northern India. | LitMetric

AI Article Synopsis

  • Trauma and accidental injuries are a major global health concern, with India experiencing the highest road accident deaths, accounting for 11% of the world's total.
  • A study from January 2023 to January 2024 analyzed wound samples from road traffic accident (RTA) patients in a northern Indian tertiary care center to assess bacterial contamination and antibiotic susceptibility.
  • Out of 189 samples, 52.38% showed microbial growth, predominantly Gram-negative bacilli, with none being resistant to colistin; 26.45% of patients developed sepsis, linked to raised procalcitonin levels and low Glasgow Coma Scale scores.

Article Abstract

Among the most significant yet often ignored health issues worldwide are trauma and accidental injuries. India accounts for 11% of global deaths in road accidents, the highest in the world, according to the World Bank report. There are limited data about the bacterial contamination of road traffic accident (RTA) wounds and their antibiotic susceptibility patterns. This prospective study was conducted in a tertiary care centre in northern India from January 2023 to January 2024. Wound deep swabs or aspirates were collected from RTA patients with traumatic injuries at different time intervals. Gram stain and culture were performed, and positive aerobic culture was subjected to antibiotic susceptibility testing. Organism identification was done using MALDI-TOF MS and routine biochemical tests. Blood samples were also collected to rule out bloodstream infections during follow-up if the patient became febrile or showed symptoms of systemic infection. Sepsis was defined in those patients who had two or more scores in the systemic inflammatory response syndrome criteria with a positive microbiological culture. Risk factors were evaluated for sepsis on the basis of the patient's vitals, injury characteristics, procalcitonin, Glasgow Coma Scale (GCS) score, need for mechanical ventilation and complete blood count, which were obtained from the patient's admission file. A total of 189 wound samples were collected, of which 99 (52.38%) samples showed the growth of microorganisms. The aerobic isolates included 69 (69.69%) Gram-negative bacilli, of which the majority were , 28 (28.28%) Gram-positive cocci, of which the majority were and 2 (2.02%) anaerobic isolates. Among the Gram-negative isolates, none of the isolates were resistant to colistin. All isolates were susceptible to vancomycin, teicoplanin and levonadifloxacin. Sepsis developed in 50 (26.45 %) patients. Significant risk factors evaluated for sepsis were a raised procalcitonin level, a low GCS score, a higher injury severity score, the need for mechanical ventilation and a raised quick sequential organ failure assessment score. It is essential to ascertain the profile of microorganisms isolated from RTA wounds in order to reduce antibiotic resistance and deliver efficient treatment.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11472858PMC
http://dx.doi.org/10.1099/acmi.0.000836.v4DOI Listing

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