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Marchiafava-Bignami Type A Disease: A Rare Neurological Manifestation in Oropharyngeal Cancer.
Cureus
December 2024
Internal Medicine Service, Pedro Hispano Hospital - Matosinhos Local Health Unit, Matosinhos, Porto, PRT.
Marchiafava-Bignami disease (MBD) is a rare condition characterized by demyelination and necrosis of the corpus callosum, most commonly associated with chronic alcohol consumption. However, it can also occur in non-alcoholic patients and may present secondary to other underlying conditions. We report a case of a 52-year-old male with no history of alcohol use or significant comorbidities, presenting with impaired consciousness and severe malnutrition.
View Article and Find Full Text PDFMarchiafava-Bignami Disease: A Case Report of a Reversible Cause of Dementia.
Cureus
November 2024
Internal Medicine, Centro Hospitalar Universitário de Santo António, Porto, PRT.
Marchiafava-Bignami disease (MBD) is a rare neurological disorder predominantly associated with chronic alcohol use, characterized by demyelination and necrosis of the corpus callosum. The condition often presents with cognitive dysfunction, motor deficits, and altered consciousness, which can range from mild confusion to severe stupor. Early recognition and treatment are crucial for improving outcomes.
View Article and Find Full Text PDFMarchiafava-Bignami Disease in a Postoperative Non-alcoholic Patient.
Cureus
October 2024
Neurology, Gujarat Cancer Society (GCS) Hospital, Ahmedabad, IND.
Marchiafava-Bignami disease (MBD) is a neuropathological condition characterized by demyelination and necrosis of the corpus callosum. This condition is commonly found in malnourished and alcoholic patients, but it is rarely observed in non-alcoholic individuals. In this case report, we describe a non-alcoholic patient who underwent two consecutive gastrointestinal surgeries.
View Article and Find Full Text PDFMarchiafava-Bignami disease with typical imaging findings: A case report.
Radiol Case Rep
January 2025
Ibn Sina University Hospital Center, Neurology A and Neuropsychology department, Rabat, Morocco.
Marchiafava-Bignami disease is a rare neurological condition characterized by necrosis and demyelination of the corpus callosum, typically associated with chronic alcoholism and/or malnutrition. The clinical manifestations of Marchiafava-Bignami disease are diverse and often nonspecific. Diagnosis of Marchiafava-Bignami disease relies on magnetic resonance imaging findings, which reveal significant and symmetrical involvement of the corpus callosum.
View Article and Find Full Text PDFRelationship between alcohol consumption and cognitive impairment in the adult population over 60 years of age: A systematic review.
Rev Colomb Psiquiatr (Engl Ed)
November 2024
Instituto de Neuropsiquiatría y Adicciones (INAD), Centros Asistenciales Dr. Emili Mira i López (CAEMIL-Recinto Torribera), Parc de Salut Mar, Santa Coloma de Gramenet, Barcelona, Spain.
Article Synopsis
- Alcohol consumption is linked to cognitive impairment in individuals aged 60 and older, with both excessive and moderate drinking influencing cognitive health.
- A systematic review of studies from 2010 to 2020 identified that excessive and prolonged alcohol use can lead to serious forms of dementia and cognitive impairment, citing notable disorders like Wernicke-Korsakoff syndrome.
- The cognitive functions most impacted by alcohol use disorder include executive functions, visuospatial skills, attention, and memory, emphasizing the risks associated with high levels of alcohol intake.
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