"All-in-One" MnO@PtAuRu Nanoreactor for Self-Replenishing and Cascade Catalytic Therapy of Cancer.

Limited by the insufficient catalytic substrates such as HO and O in the tumor microenvironment (TME), the continual propelling of nanozymes catalysis therapy of cancer remains a challenge. Here, an all-in-one MnO@PtAuRu nanoreactor is constructed for self-propelled and cascade catalytic therapy of tumors. The MnO@PtAuRu is constructed by using hollow MnO (≈150 nm) as the core-carrier and ultrasmall PtAuRu nanoclusters (≈2 nm) anchoring on the surface MnO. According to the glucose oxidase (GOD)/catalase (CAT)/peroxidase (POD) mimic multienzyme activity of PtAuRu nanoclusters, cascaded nanocatalytic reactions can be self-replenishing to persistently produce •OH for superior chemodynamic therapy (CDT). Additionally, the MnO carrier can protect the ultrasmall PtAuRu nanoclusters during the circulation and the overexpressed glutathione (GSH) in the tumor can also be degraded by the MnO to synergy the CDT. The MnO@PtAuRu displays obvious photothermal properties which further enhance the cascade catalytic ability and synergistic therapeutic effect. Therefore, this all-in-one nanozyme provides a promising strategy for the rational design of self-replenishment and self-replenishing cascade catalytic therapy of cancer.