AI Article Synopsis
- Lymphangioleiomyomatosis (LAM) is a rare lung disease affecting women, leading to decreased health-related quality of life (HRQoL), with limited understanding of the factors influencing this impairment.
- A study assessed 45 women with LAM, finding the lowest HRQoL scores in general health and vitality, while anxiety (35%) and depression (17%) were prevalent among the participants.
- Results indicated that depression symptoms and exercise capacity significantly impacted HRQoL, while lung function showed weak or no correlation with quality of life.
Article Abstract
Background: Lymphangioleiomyomatosis (LAM) is a rare (twenty-one per million female inhabitants) neoplastic cystic lung disease that impairs health-related quality of life (HRQoL). However, the factors associated with impaired quality of life in patients with LAM are poorly understood.
Objective: To assess the clinical, psychosocial, and functional characteristics associated with impaired quality of life in patients with LAM.
Methods: This was a cross-sectional study performed on two nonconsecutive days. HRQoL (SF-36 and CRQ), lung function tests, anxiety and depression symptoms (HADS), maximal (CPET and ISWT), and submaximal exercise capacity (6MWT) were assessed. Linear associations among outcomes were assessed using Pearson's correlation and multivariate tests.
Results: Forty-five women with LAM (46 ± 10.years; FEV74%pred) were evaluated. The lowest SF-36 scores were observed for general health and vitality and the highest for the physical and social domains. The lowest CRQ scores were observed for dyspnea and fatigue, and the highest were for the emotional function and self-control domains. Sixteen (35%) women had anxiety, and 8 (17%) had depression symptoms. Most of the SF-36 and CRQ domains were associated with anxiety and depression symptoms (from r = 0.4 to r = 0.7; p < 0.05) and exercise capacity (from r = 0.3 to r = 0.5; p < 0.05). Lung function parameters were weakly or not associated with quality of life domains. After multiple linear regression, HRQoL was independently associated with depression symptoms and physical capacity but not with lung function.
Conclusion: Our results show that aerobic capacity and depression symptoms are the main factors, rather than lung function, related to quality of life in patients with LAM.
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| http://dx.doi.org/10.1007/s00408-024-00751-w | DOI Listing |
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