AI Article Synopsis
- Phototheranostics utilizing near-infrared fluorescence and reactive oxygen species are effective for imaging-guided treatment of tumors through combined photo-dynamic and photo-thermal therapies.
- A new star molecule, NCBDT-4C, was created into water-dispersible nanoparticles (NPs) alongside DSPE-PEG-NH, showing optimal performance with a maximum NIR absorption peak at 764 nm and fluorescence peak at 798 nm.
- The nanoparticles can generate reactive oxygen species and heat when exposed to an 808 nm laser, demonstrating significant potential in advanced cancer treatment therapies with a quantum yield of 37.5% and a photothermal conversion efficiency of 53.6%.
Article Abstract
Phototheranostics with near-infrared fluorescence and reactive oxygen species generation ability and high photothermal conversion efficiency (PCE) plays a significant role in fluorescence imaging-guided synergetic photodynamic and photothermal therapy of tumors. Here, a star molecule in organic photovoltaic materials, NCBDT-4C with an A-D-A conjugated structure, was assembled with DSPE-PEG-NH to prepare water dispersive nanoparticles (NPs). The prepared NCBDT-4Cl NPs exhibited a maximum NIR absorption peak at 764 nm and a maximum fluorescence peak at 798 nm. These NPs could generate superoxide anion, singlet oxygen (O), and heat under 808 nm laser irradiation. The O generation quantum yield and PCE of the NPs were 37.5% and 53.6%, respectively. The combination of photodynamic and photothermal therapy of cancer was demonstrated in vitro and in vivo. This work presents the advanced application of organic photovoltaic materials in cancer phototherapy.
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| http://dx.doi.org/10.1002/bio.4930 | DOI Listing |
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