Ansa cervicalis stimulation effects on upper airway patency: a structure-based analysis.

Rationale: Ansa cervicalis stimulation (ACS) of the infrahyoid muscles has been proposed as a neurostimulation therapy for obstructive sleep apnoea (OSA). ACS stabilises the pharynx by pulling it caudally, but its specific effects on flow limitation caused by palatal, oropharyngeal lateral wall, tongue base, or epiglottis collapse remains unclear.

Objectives: To quantify the effect of ACS on collapsibility of different pharyngeal flow-limiting structures.

Methods: Participants with OSA underwent bilateral ACS during drug-induced sleep endoscopy. Maximum inspiratory airflow was assessed over a range of positive airway pressures while ACS was applied. The flow-limiting structure for each breath was classified based on manometric and endoscopic findings and a linear mixed-effects model characterised their response to ACS. The influence of patient characteristics was explored with univariate models.

Measurements And Main Results: 41 participants yielded 1761 breaths for analysis. On average, bilateral ACS decreased the observed pharyngeal critical closing ( ) and opening ( ) pressures by -3.0 (95% CI -3.6--2.3) and -3.7 (-4.4--3.0) cmHO, respectively (p<0.001). During tongue base obstruction, modelled ACS effects for and were -2.0 (-2.7--1.4) and -3.1 (-3.8--2.4) cmHO, respectively (p<0.001). Greater reductions were generally observed for other flow-limiting structures. A lower apnoea-hypopnea index was associated with a greater decrease in (p<0.01). Other patient characteristics, including body mass index, did not influence or (p>0.05).

Conclusions: Bilateral ACS decreased collapsibility of all airway flow-limiting structures. ACS generally had greater effects on palatal, oropharyngeal lateral wall and epiglottic collapse than the tongue base.