Caproic acid is an important compound for producing a variety of chemicals and a potential precursor for Sustainable Aviation Fuels (SAF). This study aimed at developing a stable mixed culture producing caproic acid using short-chain carboxylic acids (SCCAs) derived from arrested anaerobic digestion (AAD) of green waste and optimizing chain elongation (CE) conditions. The results showed that the mixed culture was dominated by Clostridium sensu stricto 12 (53.09 %), optimally producing caproic acid at 37 °C, pH 7.20, with a 15 % inoculum concentration. Under these conditions, 75.59 % of the consumed electrons contributed to caproic acid formation. Gradual ethanol feeding in bioreactor experiments resulted in caproic acid titer of 13.36 g/L, with carbon conversion efficiency (CCE) of 81.91 % and electron transfer efficiency (ETE) of 76.39 %, surpassing batch experiments without gradual ethanol addition. These findings demonstrate that the effectiveness of a mixed culture can be improved, resulting in increased caproic acid production.
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http://dx.doi.org/10.1016/j.biortech.2024.131573 | DOI Listing |
Nano Lett
January 2025
Key Laboratory of Physics and Technology for Advanced Batteries, College of Physics, Jilin University, Changchun 130012, China.
Lanthanide-doped fluoride nanocrystals have emerged as promising tools in biomedicine, yet their applications are still limited by their low luminescence efficiency. Herein, we developed highly efficient lithium-based core-shell-shell (CSS) nanoprobes (NPs) featuring a rhombic active domain and a spherical inert protective shell. By introducing Yb as an energy transfer bridge and optimizing the CSS design, a remarkable 1643-fold enhancement in visible emission and a 33-fold increase in NIR emission are achieved compared to original nanoparticles.
View Article and Find Full Text PDFFront Nutr
December 2024
Department of Spleen and Stomach Diseases, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Introduction: Alcoholic liver disease (ALD) is a pathological state of the liver caused by longterm alcohol consumption. Recent studies have shown that the modulation of the gut microbiota and its metabolic products, specifically the short-chain fatty acids (SCFAs), exert a critical role in the evolution and progression of ALD. The Liuweizhiji Gegen-Sangshen beverage (LGS), as a functional beverage in China, is derived from a traditional Chinese herbal formula and has been clinically applied for ALD treatment, demonstrating significant efficacy.
View Article and Find Full Text PDFMetabolites
December 2024
School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, China.
Background: Our previous study showed that antibiotic exposure was linked to depressive symptomatology in community-dwelling older adults in China. Our current study aims to explore the underlying mechanisms by assessing the intermediated effects of circulating short-chain organic acids (SCOAs) on this association.
Methods: Depressive symptoms were screened by the 30-item Geriatric Depression Scale (GDS-30).
Gels
December 2024
Faculty of Chemical Sciences and Engineering, Autonomous University of Baja California, University Boulevard No. 14418, Otay Mesa, Tijuana 22390, Mexico.
This study aims to design microgels that are thermo- and pH-sensitive for controlled doxorubicin (Dox) release in response to tumor microenvironment changes. N-isopropylacrylamide (NIPAAm) is widely used for thermoresponsive tumor-targeted drug delivery systems for the release of therapeutic payloads in response to temperature changes. Herein, a NIPAAm microgel (MP) that is responsive to temperature and pH was designed for the smart delivery of Dox.
View Article and Find Full Text PDFBMC Vet Res
December 2024
College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, 453003, China.
Marbling is a key indicator of the meat quality of ruminants. Gastrointestinal microbiota may regulate the formation of marbling by influencing the nutritional metabolism of animals. This study analyzed the composition and functional differences of microbiota in the rumen and cecum, the differences in volatile fatty acids (VFAs) content in the longissimus thoracis muscle, and the differences in protein abundance in the longissimus thoracis muscle of ruminants with different marbling grades through microbiome-proteome analysis.
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