Polyglycolic acid (PGA), a novel type of hazardous biodegradable plastic, is gradually being widely used in the biomedical and food packaging industries. However, the long-term ecological effects of PGA degradation to microplastics (MPs) in aquatic organisms remain unknown. The gut-liver-brain axis regulates the exchange of information between the gut, liver, and brain, and is a key target for tissue damage caused by pollutants. Adult zebrafish were exposed to 1 or 100 mg/L PGA MP suspension for 28 d. PGA affects the intestinal vascular barrier through gene expression downstream of the Wnt/β-catenin pathway, increasing intestinal permeability and disrupting the environment of intestinal microbial diversity. This, in turn, promoted the accumulation of lipopolysaccharide (LPS). Disturbance of the intestinal microbiota balance and its metabolites are transferred to the liver and brain through the gut-liver-brain axis, causing disorders in hepatic lipid metabolism and synthesis. Behavioural experiments showed that long-term exposure to PGA MP caused anxiety-like behaviour and cognitive impairment, which may be related to the disruption of the gut-liver-brain axis, thus inducing inflammation and disrupting the normal functioning of the body. In summary, this study evaluated the safety of the new degradable plastic, PGA, but its ecological risks still require attention.
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