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Response by Hoedemakers et al to Letter Regarding Article, "mPAP/CO Slope and Oxygen Uptake Add Prognostic Value in Aortic Stenosis".
Circulation
October 2024
Department of Cardiology, Jessa Hospital, Hasselt, Belgium (S.H., L.H., J.V.).
Defining good health and care from the perspective of persons with multimorbidity: results from a qualitative study of focus groups in eight European countries.
BMJ Open
August 2018
Erasmus School of Health Policy & Management, Erasmus University Rotterdam, Rotterdam, The Netherlands.
Objectives: The prevalence of multimorbidity is increasing in many Western countries. Persons with multimorbidity often experience a lack of alignment in the care that multiple health and social care organisations provide. As a response, integrated care programmes are appearing.
View Article and Find Full Text PDFPortal and systemic serum growth factor and acute-phase response after laparotomy or partial hepatectomy in patients with colorectal liver metastases: a prognostic role for C-reactive protein and hepatocyte growth factor.
Scand J Gastroenterol
November 2004
Department of Surgery, Division of Hepato-Pancreato-Biliary Surgery & Liver Transplantation, University Hospital and Medical Faculty of the University of Groningen, 9700 RB Groningen, The Netherlands.
Background: Growth factors play a role in wound healing and tumour growth. The aim of this study was to compare the effect of partial hepatectomy (PH) and laparotomy on serum levels of growth factors and acute-phase proteins in patients with colorectal liver metastases and to correlate these levels with prognosis after PH.
Methods: Epidermal growth factor (EGF), hepatocyte growth factor (HGF), insulin like growth factor-I (IGF-I), insulin, interleukin-6 (IL-6), C-reactive protein (CRP) and serum amyloid-A (SAA) were determined in portal and systemic serum in 24 PH patients and 9 laparotomy patients.
Heterogeneity in secretory responses of rat liver macrophages of different size.
Liver
December 1995
Groningen Institute for Drug Studies (GIDS), State University Groningen, The Netherlands.
Four subpopulations of hepatic macrophages, differing in size, were isolated from rat liver. The secretion of nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), prostaglandin E (PGE) and interleukin-1 (IL-1) by freshly isolated as well as cultured cells was studied after in vitro stimulation with the immunomodulator muramyl dipeptide (MDP) in free or liposome-encapsulated form. Freshly isolated liver macrophages could be induced to secrete significant levels of NO, TNF-alpha, PGE and IL-1.
View Article and Find Full Text PDFProliferation of rat liver macrophages in vitro: influence of hemopoietic growth factors.
Hepatology
March 1994
Groningen Institute for Drug Studies, State University Groningen, The Netherlands.
We examined the effects of several hemopoietic growth factors on proliferation of rat liver macrophages in vitro. The proliferative response of liver macrophages to hemopoietic growth factors was assayed on the basis of [methyl-3H]thymidine uptake. Macrophage colony-stimulating factor and recombinant murine granulocyte-macrophage colony-stimulating factor stimulated [methyl-3H]thymidine incorporation in a concentration-dependent manner.
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