AI Article Synopsis
- Autosomal dominant polycystic kidney disease (ADPKD) is linked to mutations in the PKD1 and PKD2 genes and leads to kidney failure, with progression rates varying among patients due to additional underlying factors.
- This study examined how disrupting the circadian clock by deleting the Bmal1 gene in specific mouse models affects the progression of ADPKD, revealing significant changes in gene expression and increased disease severity.
- Findings indicated that Bmal1 gene deletion led to enhanced cyst growth, altered lipid metabolism, and greater cell proliferation, suggesting that circadian rhythm disruption exacerbates ADPKD progression through its impact on lipid metabolism.
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| http://dx.doi.org/10.1681/ASN.0000000528 | DOI Listing |
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