AI Article Synopsis
- A new bicyclo[3.3.1]nonadienemethanol-type lignan called 9,9'-oxidolanceolatanin B, along with four known lignans, was isolated from Zucc. leaves through a study focusing on α-glucosidase inhibition.
- The structure of 9,9'-oxidolanceolanceolatanin B was determined using NMR spectroscopy and ECD data.
- All isolated compounds exhibited stronger α-glucosidase inhibitory effects than the standard drug acarbose, suggesting that Zucc. leaves may be a valuable source for developing plant-based anti-diabetic treatments.
Article Abstract
Following an α-glucosidase inhibitory activity-guided phytochemical study, a rare new bicyclo[3.3.1]nonadienemethanol-type lignan named 9,9'-oxidolanceolatanin B () and four known lignans, lanceolatanin B (), pinoresinol (), syringaresinol (), and medioresinol (), were isolated from a CHCl-soluble fraction of Zucc. leaves. The absolute configuration of 9,9'-oxidolanceolatanin B was elucidated based on NMR spectroscopic interpretation and ECD data. All isolated compounds - showed stronger α-glucosidase inhibitory potency than the positive control, acarbose. This data could support the conceit that leaves could be a promising source for plant-based anti-diabetic drug discovery.
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| http://dx.doi.org/10.1080/14786419.2024.2414407 | DOI Listing |
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