AI Article Synopsis
- The study aimed to find cardiovascular ultrasound indicators that could predict brain abnormalities in fetuses diagnosed with heart disease.
- After reviewing 2705 studies, researchers narrowed it down to 10 relevant ones, which highlighted significant changes in fetal brain development linked to specific cardiovascular conditions.
- Key findings included decreased fetal head size and brain volume, with notable statistical correlations to hypoxia-related changes and specific blood flow measurements in the heart and aorta.
Article Abstract
Objective: To identify cardiovascular ultrasound predictors for brain anomalies in fetuses with heart disease.
Methods: A literature search was performed in the following databases: MEDLINE through OVID, EMBASE, Cochrane Registry Center for Controlled Trials (CENTRAL), and LILACS, from their inception until May 2023. Clinical studies, cross-sectional studies, case-control studies, cohorts, and systematic reviews were included. Data extraction was performed, and the risk of bias was assessed using the QUADAS-2 tool.
Results: Among 2705 studies evaluated, after filtering information, 10 articles were selected that met the inclusion criteria. These studies noted the following outcomes: a decrease in fetal head circumference, changes in brain maturation measured in days, decreased depth of brain fissures, and a decrease in total brain volume. The studies show a statistically significant correlation with the presence of the following cardiovascular predictors: low or mixed oxygen content in the ascending aorta (p < 0.001), retrograde flow in the aortic arch (p < 0.001), lower z values of the MCA-PI (p < 0.05), higher UA-PI z values (p < 0.01), and lower CPR (p < 0.05). In addition, lower values of left ventricular flow (p < 0.01), ductus arteriosus (p < 0.0001), and combined cardiac output index (p < 0.01) were reported.
Conclusions: This review describes the most relevant evidence correlating the effects of hemodynamic changes that lead to states of chronic hypoxia related to the aforementioned changes in the central nervous system.
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| http://dx.doi.org/10.1002/bdr2.2402 | DOI Listing |
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